Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 13/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL30241166 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL4400214 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL3504 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL30384019 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1649454 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL29460464 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL18171844 | 0.95 | PTGS2 (0.90) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1462647 | 0.89 | PTGS2 (0.79) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1538458 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL8531474 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809303-A4 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC PHARMACEUTICALS INC (CA) | 2008-12-24 | — | — | EP | claimed |
| EP-1809303-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC PHARMACEUTICALS, INC. (CA) | 2007-07-25 | — | — | EP | claimed |
| WO-2006032143-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC PHARMACEUTICALS, INC. (CA) | 2006-03-30 | — | — | WO | claimed |
| WO-2006032144-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING FUCANS FROM VARIOUS ECHINODERM SOURCES | ARC PHARMACEUTICALS, INC. (CA) | 2006-03-30 | — | — | WO | claimed |
| EP-1631265-A2 | USE OF VARIOUS AGENTS FOR INHIBITING FIBROUS ADHESIONS | ARC PHARMACEUTICALS, INC. (CA) | 2006-03-08 | — | — | EP | claimed |
| WO-2004105737-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS USING VARIOUS AGENTS | ARC PHARMACEUTICALS, INC. (CA) | 2004-12-09 | — | — | WO | claimed |
| US-20040235954-A1 | Method for treatment of premature ejaculation in humans | JEFFERSON BANK | 2004-11-25 | — | — | US | claimed |
| WO-2004043365-A2 | METHOD FOR TREATMENT OF PREMATURE EJACULATION IN HUMANS | AZAYA THERAPEUTICS, INC. (US) | 2004-05-27 | — | — | WO | claimed |
| US-20200338114-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES INC. (CA) | 2020-10-29 | — | — | US | disclosed |
| US-20170252367-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES, INC. (CA) | 2017-09-07 | — | — | US | disclosed |
| US-20170246202-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES, INC. (CA) | 2017-08-31 | — | — | US | disclosed |
| US-20140256672-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES, INC. (CA) | 2014-09-11 | — | — | US | disclosed |
| US-20140135283-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES, INC. (CA) | 2014-05-15 | — | — | US | disclosed |
| US-20110250275-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS | ARC MEDICAL DEVICES, INC. (CA) | 2011-10-13 | — | — | US | disclosed |
| US-6368788-B1 | IMMUNOSUPPRESSANTS FOR HTLV AND VIRICIDES | CYTRAN, INC. | 2002-04-09 | — | — | US | disclosed |
| US-5811399-A | Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants | CYTRAN, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| US-5807830-A | ADMINISTERING GLUTAMIC ACID, TRYPTOPHAN DIPEPTIDE | CYTOVEN J.V. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5770576-A | ADMINISTERING GLUTAMIC ACID-TRYPTOPHAN DIPEPTIDE TO STIMULATE BINDING FUNCTION OF T-LYMPHOCYTES | CYTRAN, INC. (US) | 1998-06-23 | — | — | US | disclosed |
| US-5728680-A | ADMINISTERING GLUTAMIC ACID-TRYPTOPHAN DIPEPTIDE; IMMUNOMODULATION | CYTOVEN J.V. (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1994020063-A2 | PHARMACEUTICAL TRYPTOPHAN CONTAINING DIPEPTIDE COMPOSITIONS AND METHODS OF USE THEREOF | CYTOVEN INTERNATIONAL N.V. (US) | 1994-09-15 | — | — | WO | disclosed |