Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 13/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL30241166 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL4400214 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1874563 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL30384019 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1649454 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL29460464 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL18171844 | 0.95 | PTGS2 (0.90) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1462647 | 0.89 | PTGS2 (0.79) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1538458 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL8531474 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11236 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662203-A1 | BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS | Translatum Medicus Inc. (CA) | 2025-12-17 | — | — | EP | claimed |
| US-20250333792-A1 | GENE PANEL FOR IDENTIFYING HYPO SEPSIS PHENOTYPE PATIENTS | UNIV FLORIDA (US) | 2025-10-30 | — | — | US | claimed |
| WO-2025132620-A1 | STABLE SOFT CAPSULE PREPARATIONS WITH SOLID FILL FOR MOISTURE SENSITIVE ACTIVE INGREDIENTS | BAYER CONSUMER CARE AG (CH) | 2025-06-26 | — | — | WO | claimed |
| CN-119997773-A | Inverted perovskite solar cell based on recrystallization and preparation method thereof | 中国科学院宁波材料技术与工程研究所 | 2025-05-13 | — | — | CN | claimed |
| US-20250099590-A1 | HIGH DENSITY ULTRASOUND COUPLING GEL AND METHODS OF USE THEREOF | ZETROZ SYSTEMS LLC (US) | 2025-03-27 | — | — | US | claimed |
| WO-2025054169-A1 | COMPOSITIONS AND METHODS FOR TOPICAL TREATMENT | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2025-03-13 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-20250017846-A1 | TOPICAL ANALGESICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2025-01-16 | — | — | US | claimed |
| EP-3638673-B9 | TETRAHYDROPYRIDOPYRAZINE MODULATORS OF GPR6 | TAKEDA PHARMACEUTICALS CO (JP) | 2024-11-20 | — | — | EP | claimed |
| EP-4433090-A1 | METHODS OF TREATING HEADACHES AND MIGRAINES WITH SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 11 (SCN11A) INHIBITORS | Regeneron Pharmaceuticals, Inc. (US) | 2024-09-25 | — | — | EP | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| EP-0047225-B1 | ACCESSORY FOR SEWING MACHINE | FRITZ GEGAUF AG BERNINA-NÄHMASCHINENFABRIK (CH) | 1984-01-11 | — | — | EP | claimed |
| EP-0090693-A1 | Device for marking the position of printed circuit boards with respect to their connectors | Ozil, Maurice (FR) | 1983-10-05 | — | — | EP | claimed |
| EP-0087395-A1 | Process and sewing machine for quilting superposed layers of fabric delivered from rolls of fabric and cut transversely after quilting | "I.M."- S.r.l. (IT) | 1983-08-31 | — | — | EP | claimed |
| EP-0016751-B1 | A MULTI CYLINDER INTERNAL COMBUSTION ENGINE | FORD-WERKE AKTIENGESELLSCHAFT (DE) | 1983-02-16 | — | — | EP | claimed |
| EP-0069106-A1 | Machine for sawing stone blocks | NORTON COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| EP-0006648-B1 | METHOD AND DEVICE FOR INSPECTING A MOVING SHEET MATERIAL FOR STREAKLIKE DEFECTS | AGFA-GEVAERT N.V. (BE) | 1982-04-14 | — | — | EP | claimed |
| EP-0035621-A1 | Apparatus for the identification and indication of notes generated by a musical instrument | Roses, Henri (FR) | 1981-09-16 | — | — | EP | claimed |
| WO-1981001898-A1 | INDICATOR APPARATUS FOR INDICATING NOTES EMITTED BY MEANS OF A MUSICAL INSTRUMENT | ROSES H | 1981-07-09 | — | — | WO | claimed |
| EP-0006575-A1 | Apparatus for preparing foodstuffs from cooked and expanded cereals | Gevaert, Omer (BE) | 1980-01-09 | — | — | EP | claimed |