Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 13/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL30241166 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL3504 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1874563 | 1.00 | PTGS2 (1.00) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL30384019 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1649454 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL29460464 | 0.99 | PTGS2 (0.97) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL18171844 | 0.95 | PTGS2 (0.90) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1462647 | 0.89 | PTGS2 (0.79) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL1538458 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN | |
| Meclofenamic Acid SCHEMBL8531474 | 0.88 | PTGS2 (0.77) | PTGS2MEN1MAPK1KMT2AGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557088-B2 | Methods and compositions for treating conditions | NEOPRO LABS, LLC (US) | 2009-07-07 | — | — | US | disclosed |
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| WO-1998013073-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-04-02 | — | — | WO | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |