Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 17/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 17/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043449 | 0.86 | POLB (0.71) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1043806 | 0.84 | POLB (0.60) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1874665 | 0.83 | POLB (0.52) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1044197 | 0.83 | POLB (0.55) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1078455 | 0.80 | HTR6 (0.48) | ADRA1DADRA1AADRA1BLMNAPOLB | |
| SCHEMBL1043743 | 0.77 | POLB (0.45) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| Ambenoxan SCHEMBL2109415 | 0.76 | ADRA1D (0.64) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1888021 | 0.74 | HTR6 (0.52) | ADRA1DADRA1AADRA1BMEN1CYP3A4 | |
| SCHEMBL1450868 | 0.72 | HTT (0.39) | ADRA1APOLBESR2HTR1AALDH1A1 | |
| SCHEMBL1876029 | 0.72 | CA2 (0.45) | ADRA1DADRA1AADRA1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-05-05 | — | — | US | claimed |
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | DBH, SLC18A2, SLC6A3 | ADRA1D 30/4885ADRA1A 45/4885ADRA1B 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.