Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL1874881 | 0.89 | POLB (0.33) | POLBBCHEACHEALDH1A1 | |
| Methacrylic Acid SCHEMBL14675435 | 0.88 | BBOX1 (0.32) | POLBALDH1A1 | |
| Sulfuric Acid Dimethyl Ester SCHEMBL27628757 | 0.87 | ALDH1A1 (0.32) | ALDH1A1 | |
| Methacrylic Acid SCHEMBL14675436 | 0.86 | TSHR (0.32) | ALDH1A1 | |
| Methacrylic Acid SCHEMBL9636345 | 0.82 | TSHR (0.33) | POLBALDH1A1 | |
| SCHEMBL638497 | 0.82 | POLB (0.42) | POLBBCHEACHE | |
| Methacrylic Acid SCHEMBL1713812 | 0.82 | TSHR (0.39) | POLBACHEALDH1A1 | |
| Methacrylic Acid SCHEMBL20917781 | 0.80 | TSHR (0.38) | POLBACHEALDH1A1 | |
| Methacrylic Acid SCHEMBL2059649 | 0.80 | ALDH1A1 (0.42) | POLBACHEALDH1A1 | |
| SCHEMBL27917744 | 0.79 | BBOX1 (0.34) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013018356-A1 | METHOD FOR PRODUCING COMPOSITE PARTICLE, METHOD FOR PRODUCING COSMETIC, AND COSMETIC | SHIN-ETSU CHEMICAL CO.,LTD. (JP) | 2013-02-07 | — | — | WO | disclosed |
| EP-2397505-A1 | High water content silicone hydrogels | Bausch & Lomb Incorporated (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2222736-B1 | HIGH WATER CONTENT SILICONE HYDROGELS | BAUSCH & LOMB (US) | 2011-09-21 | — | — | EP | disclosed |
| US-7934830-B2 | High water content silicone hydrogels | BAUSCH & LOMB INCORPORATED (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935748-B2 | Adjuvant for hydraulic compositions | LAFARGE SA (FR) | 2011-05-03 | — | — | US | disclosed |
| EP-2222736-A1 | HIGH WATER CONTENT SILICONE HYDROGELS | Bausch & Lomb Incorporated (US) | 2010-09-01 | — | — | EP | disclosed |
| CN-101626956-A | Packaging system for contact lenses | BAUSCH & LOMB | 2010-01-13 | — | — | CN | disclosed |
| EP-2121450-A1 | PACKAGING SYSTEM FOR CONTACT LENSES | Bausch & Lomb Incorporated (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2009073321-A1 | HIGH WATER CONTENT SILICONE HYDROGELS | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |
| US-20090141234-A1 | High Water Content Silicone Hydrogels | BAUSCH HEALTH AMERICAS, INC. | 2009-06-04 | — | — | US | disclosed |
| US-7201481-B2 | Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer | NOVARTIS AG (CH) | 2007-04-10 | — | — | US | disclosed |
| EP-1236068-A4 | CONTACT LENS | NOVARTIS AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| US-20060012751-A1 | Contact lens | ALCON INC. (CH) | 2006-01-19 | — | — | US | disclosed |
| US-6649722-B2 | Interpolymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group- containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer | NOVARTIS AG (CH) | 2003-11-18 | — | — | US | disclosed |
| EP-1236068-A1 | CONTACT LENS | Novartis AG (CH) | 2002-09-04 | — | — | EP | disclosed |
| US-20020107337-A1 | Contact lens | ALCON INC. (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2001042846-A1 | CONTACT LENS | WESLEY JESSEN CORPORATION (US) | 2001-06-14 | — | — | WO | disclosed |
| US-5149752-A | Comprising quarternized (meth)acrylate homo- and copolymers having urethane or urea groups; shampoo or hair conditioner | CLAIROL INCORPORATED (US) | 1992-09-22 | — | — | US | disclosed |
| US-5147635-A | For hair | CLAIROL INCORPORATED (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0251348-B1 | WATER-SOLUBLE SACCHARIDE POLYMERS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-12-19 | — | — | EP | disclosed |