Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL14675436 | 0.91 | TSHR (0.32) | TSHRCYP2C19ALDH1A1LMNAAPEX1 | |
| Methacrylic Acid SCHEMBL1713812 | 0.91 | TSHR (0.39) | TSHRCYP2C19ALDH1A1LMNAAPEX1 | |
| Methacrylic Acid SCHEMBL14675435 | 0.89 | BBOX1 (0.32) | TSHRCYP2C19ALDH1A1LMNAAPEX1 | |
| Methacrylic Acid SCHEMBL20917781 | 0.88 | TSHR (0.38) | TSHRCYP2C19ALDH1A1LMNAAPEX1 | |
| Methacrylic Acid SCHEMBL2059649 | 0.88 | ALDH1A1 (0.42) | TSHRCYP2C19ALDH1A1LMNAAPEX1 | |
| Sulfuric Acid Dimethyl Ester SCHEMBL27628757 | 0.84 | ALDH1A1 (0.32) | ALDH1A1LMNA | |
| Methacrylic Acid SCHEMBL1998337 | 0.83 | TDP1 (0.35) | TSHRALDH1A1TGFBR1TDP1 | |
| Methacrylic Acid SCHEMBL6862647 | 0.83 | TDP1 (0.42) | TSHRALDH1A1LMNATGFBR1TDP1 | |
| Methacrylic Acid SCHEMBL999438 | 0.83 | TDP1 (0.42) | TSHRALDH1A1LMNATGFBR1TDP1 | |
| Methacrylic Acid SCHEMBL1874883 | 0.82 | POLB (0.33) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021112219-A1 | SLUDGE DEHYDRATING AGENT AND SLUDGE DEHYDRATION METHOD | 栗田工業株式会社 | 2021-06-10 | — | — | WO | disclosed |
| EP-0083377-B2 | SILVER HALIDE COLOR PHOTOGRAPHIC SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| EP-0083377-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1986-10-15 | — | — | EP | disclosed |
| US-4446226-A | SIVER IODOBROMIDE, SILVER IODIDE, CRYSTAL STRUCTURE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0083377-A1 | SILVER HALIDE COLOR PHOTOGRAPHIC SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1983-07-13 | — | — | EP | disclosed |
| EP-0070183-A1 | Light-sensitive color photographic material | KONICA CORPORATION (JP) | 1983-01-19 | — | — | EP | disclosed |