Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.46 |
| ▸ | FCER2 | P06734 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 9/20 | 0.43 |
| ▸ | MMP3 | P08254 | 8/20 | 0.43 |
| ▸ | MMP7 | P09237 | 7/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22199401 | 0.85 | CTSS (0.50) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL22927776 | 0.81 | CTSS (0.67) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL25976737 | 0.80 | CTSS (0.55) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL25773989 | 0.80 | CTSS (0.52) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL23380577 | 0.79 | CTSS (0.57) | CTSSCTSLCTSBCTSK | |
| SCHEMBL20880680 | 0.78 | CTSS (0.53) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL25751083 | 0.78 | CTSS (0.50) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL19290000 | 0.77 | HDAC3 (0.48) | CTSSCTSKHDAC3HDAC4HDAC1 | |
| SCHEMBL18513842 | 0.77 | CTSS (0.54) | MMP1FCER2CTSSCTSLCTSB | |
| SCHEMBL24380508 | 0.77 | OPRD1 (0.53) | MMP1FCER2CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753178-B1 | PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES | SEATTLE GENETICS INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-2751111-B1 | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases | MEDIMMUNE LTD (GB) | 2017-04-26 | — | — | EP | disclosed |
| EP-2751110-B1 | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative and autoimmune diseases | MEDIMMUNE LTD (GB) | 2017-04-19 | — | — | EP | disclosed |