Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 12/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.42 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876709 | 0.82 | SLC6A3 (0.48) | SCN1ASCN5ASCN8ASLC6A3SLC6A2 | |
| SCHEMBL1875311 | 0.70 | SCN1A (0.42) | SCN1ASCN5ASCN8ASCN1BNR1I2 | |
| SCHEMBL31111607 | 0.69 | CA12 (0.41) | CYP2C9IDO1TDO2 | |
| Hydrochloric Acid SCHEMBL31111474 | 0.68 | CA12 (0.40) | CYP2C9IDO1TDO2 | |
| SCHEMBL27950179 | 0.64 | L3MBTL1 (0.44) | CYP2C9SLC6A3 | |
| SCHEMBL1873870 | 0.63 | IDO1 (0.35) | SCN1ASCN5ASCN8ASCN1BNR1I2 | |
| SCHEMBL27485236 | 0.63 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL20502514 | 0.61 | GAA (0.39) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL28220056 | 0.61 | IDO1 (0.39) | CYP2C9IDO1TDO2 | |
| Hydrochloric Acid SCHEMBL4757638 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |