Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875309 | 0.82 | SCN1A (0.42) | SLC6A3SLC6A2SLC6A4SCN1ASCN5A | |
| SCHEMBL1874631 | 0.75 | CA1 (0.35) | CA12CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL320519 | 0.69 | HRH1 (0.52) | SLC6A3SLC6A2SLC6A4CA12CA1 | |
| SCHEMBL3472313 | 0.69 | AOC3 (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1876712 | 0.68 | SLC6A3 (0.40) | SLC6A3SLC6A2SLC6A4CA12CA1 | |
| SCHEMBL28432289 | 0.68 | MMP13 (0.52) | GAAMEN1KMT2ATDP1CA12 | |
| SCHEMBL564038 | 0.66 | POLB (0.43) | TDP1CA1CA2CA7CA9 | |
| SCHEMBL3376828 | 0.66 | TAAR1 (0.50) | SLC6A3SLC6A2SLC6A4CA12CA1 | |
| SCHEMBL4226373 | 0.66 | CA2 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7642636 | 0.66 | MMP13 (0.35) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |