Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753860 | 0.87 | LRRK2 (0.45) | ALDH1A1LMNA | |
| SCHEMBL18753315 | 0.87 | HCRTR1 (0.46) | ABL1BCRSLC6A7GAA | |
| SCHEMBL18753740 | 0.84 | LMNA (0.48) | ABL1BCRMEN1KMT2AALDH1A1 | |
| SCHEMBL18753487 | 0.83 | ALDH1A1 (0.54) | ABL1BCRL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL18753318 | 0.82 | KMT2A (0.59) | ABL1BCRMEN1KMT2AALDH1A1 | |
| SCHEMBL18753467 | 0.82 | L3MBTL1 (0.56) | PKLRABL1BCRL3MBTL1MEN1 | |
| SCHEMBL18753307 | 0.81 | TSHR (0.47) | L3MBTL1ALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL18753353 | 0.81 | HPGD (0.51) | PKLRABL1BCRL3MBTL1MEN1 | |
| SCHEMBL18753372 | 0.81 | HCRTR1 (0.46) | PKLRABL1BCRKMT2AALDH1A1 | |
| SCHEMBL18753811 | 0.81 | PKM (0.55) | ABL1BCRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3241554-A1 | QUINOLINE-8-SULFONAMIDE DERIVATES HAVING AN ANTICANCER ACTIVITY | Agios Pharmaceuticals, Inc. (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |