Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753738 | 0.87 | PKM (0.48) | MYCHPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL18753869 | 0.86 | MYC (0.49) | MYCLMNAALDH1A1LRRK2 | |
| SCHEMBL18753811 | 0.85 | PKM (0.55) | MYCABL1BCRKMT2AMEN1 | |
| SCHEMBL18753307 | 0.83 | TSHR (0.47) | HPGDLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL18753318 | 0.82 | KMT2A (0.59) | HPGDABL1BCRLMNASMN1; SMN2 | |
| SCHEMBL18753740 | 0.82 | LMNA (0.48) | ABL1BCRLMNASMN1; SMN2KMT2A | |
| SCHEMBL18753852 | 0.82 | POLB (0.45) | MYCHPGDABL1BCRKMT2A | |
| SCHEMBL18753355 | 0.81 | ABL1 (0.46) | HPGDABL1BCRLMNASMN1; SMN2 | |
| SCHEMBL18753306 | 0.79 | GBA1 (0.44) | HPGDLMNAGAA | |
| SCHEMBL18753487 | 0.79 | ALDH1A1 (0.54) | HPGDABL1BCRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |