Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19561846 | 0.89 | POLB (0.47) | KMT2AMEN1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL18753804 | 0.87 | KMT2A (0.55) | ALDH1A1KMT2AMEN1HSD11B1GPR183 | |
| SCHEMBL19562194 | 0.81 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL18753307 | 0.79 | TSHR (0.47) | ALDH1A1KDM4ETSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL18753487 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD11B1KDM4ETSHR | |
| SCHEMBL18753318 | 0.78 | KMT2A (0.59) | ALDH1A1KMT2AMEN1HSD11B1TSHR | |
| SCHEMBL18753467 | 0.78 | L3MBTL1 (0.56) | ALDH1A1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL18753480 | 0.78 | POLB (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL18753740 | 0.77 | LMNA (0.48) | ALDH1A1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL18753811 | 0.76 | PKM (0.55) | ALDH1A1KMT2AMEN1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |