Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933232 | 0.85 | MAPT (0.45) | ALDH1A1MAPTPOLBPTGS2L3MBTL1 | |
| SCHEMBL7322411 | 0.82 | CA2 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19LMNA | |
| SCHEMBL7322406 | 0.82 | CA2 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19LMNA | |
| SCHEMBL19931120 | 0.80 | ALDH1A1 (0.42) | ALDH1A1TUBB1CYP1A2CYP2D6HPGD | |
| SCHEMBL14137007 | 0.78 | ACHE (0.39) | ALDH1A1LMNAMAPTMAPK1KDM4E | |
| SCHEMBL19931525 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TUBB1CYP1A2CYP2D6HPGD | |
| SCHEMBL6996590 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDLMNAMAPTMAPK1 | |
| SCHEMBL20780326 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CYP2D6KMT2AMEN1MAPT | |
| SCHEMBL21648866 | 0.74 | RIPK1 (0.36) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL23624947 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978754-B1 | BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-10 | — | — | EP | disclosed |
| EP-2978747-B1 | BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-04-19 | — | — | EP | disclosed |