Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452871 | 0.77 | MAOA (0.42) | ALDH1A1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL18758026 | 0.75 | CYP3A4 (0.44) | CYP3A4ALDH1A1TSHRMAPK1TDP1 | |
| SCHEMBL873511 | 0.74 | SMN1; SMN2 (0.39) | CYP3A4ALDH1A1MAPK1MEN1MAPT | |
| SCHEMBL5313141 | 0.74 | CYP3A4 (0.46) | CYP3A4CASP1RECQLALDH1A1TSHR | |
| SCHEMBL18757779 | 0.73 | CYP3A4 (0.41) | CYP3A4CASP1RECQLALDH1A1TDP1 | |
| SCHEMBL19931108 | 0.73 | CYP3A4 (0.41) | CYP3A4CASP1RECQLALDH1A1TSHR | |
| SCHEMBL22966843 | 0.73 | ALDH1A1 (0.46) | ALDH1A1TSHR | |
| SCHEMBL28303061 | 0.73 | SMN1; SMN2 (0.38) | CYP3A4ALDH1A1MAPK1MEN1MAPT | |
| Hydrochloric Acid SCHEMBL28797568 | 0.73 | SMN1; SMN2 (0.38) | CYP3A4ALDH1A1MAPK1MEN1MAPT | |
| Hydrochloric Acid SCHEMBL27555401 | 0.72 | HSD17B10 (0.44) | CYP3A4CASP1RECQLALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039829-A1 | INHIBITORS OF KIF18A AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |
| WO-2023212240-A1 | COMPOUNDS FOR INHIBITING KIF18A | VOLASTRA THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2022269384-A1 | A PROCESS FOR THE DIRECT SYNTHESIS OF FEDRATINIB INTERMEDIATE | AMI ORGANICS LTD. (IN) | 2022-12-29 | — | — | WO | disclosed |
| WO-2017066428-A1 | BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-04-20 | — | — | WO | disclosed |