Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.46 |
| ▸ | MDM4 | O15151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29445631 | 0.84 | CASP3 (0.45) | CASP3MDM4TP53MDM2 | |
| SCHEMBL10074077 | 0.83 | CASP3 (0.44) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL3039215 | 0.79 | CASP3 (0.57) | CASP3MDM4TP53KMT2AEPHX2 | |
| SCHEMBL13323320 | 0.79 | CASP3 (0.57) | CASP3MDM4TP53KMT2AEPHX2 | |
| SCHEMBL8355967 | 0.79 | CASP3 (0.57) | CASP3MDM4TP53KMT2AEPHX2 | |
| SCHEMBL29664082 | 0.79 | CASP3 (0.57) | CASP3MDM4TP53KMT2AEPHX2 | |
| SCHEMBL13778142 | 0.79 | CASP3 (0.56) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL29354463 | 0.79 | CASP3 (0.56) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL3123838 | 0.77 | CASP3 (0.51) | CASP3MDM4TP53KMT2AEPHX2 | |
| SCHEMBL13570148 | 0.77 | CASP3 (0.60) | CASP3MDM4TP53KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107255-A1 | APELIN POLYPEPTIDES | AMGEN INC. (US) | 2017-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107255-A1 | APELIN POLYPEPTIDES | APLNR, FABP3, AP3B1 | CASP3 785/4885MDM4 3836/4885TP53 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.