Dimethindene

Dimethindene

SCHEMBL18759

CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Dimethindene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 8/20 1.00
CHRM1 P11229 20/20 1.00
CHRM2 P08172 19/20 1.00
CHRM4 P08173 19/20 1.00
CHRM5 P08912 19/20 1.00
CHRM3 P20309 19/20 1.00
CYP2D6 P10635 3/20 1.00
KCNH2 Q12809 3/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2C9 P11712 1/20 1.00
TSHR P16473 1/20 1.00
CYP2C19 P33261 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
DRD1 P21728 1/20 1.00
PTGS1 P23219 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
OPRM1 P35372 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(S)-(+)-Dimethindene SCHEMBL30910954 1.00 CHRM1 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL30436315 1.00 CHRM1 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL29676184 1.00 CHRM1 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL19284560 1.00 CHRM1 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL1972832 0.90 CHRM1 (0.82) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL29455130 0.90 CHRM1 (0.82) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL359490 0.90 CHRM1 (0.82) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL29887834 0.90 CHRM1 (0.82) CHRM1CHRM2CHRM4CHRM5CHRM3
Dimethindene SCHEMBL28142887 0.87 CHRM1 (0.76) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL6276908 0.87 HRH1 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5572 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
EP-4637708-A2 SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE Novaliq GmbH (DE) 2025-10-29 EP claimed
EP-4630401-A2 CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF Rutgers, the State University of New Jersey (US) 2025-10-15 EP claimed
US-12427109-B2 Natural origin stabilizer for oil in water emulsions FUNDACIÓN CIDETEC (ES) 2025-09-30 US claimed
EP-4154879-B1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS KOREA INST SCI & TECH (KR) 2025-09-10 EP claimed
US-20250177398-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-06-05 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12263168-B2 Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type 2 inflammation RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-04-01 US claimed
US-20250099498-A1 STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION GALLEON LABS LLC (US) 2025-03-27 US claimed
EP-0783886-A2 Use of taxol for the manufacture of a medicament for the treatment of cancer BRISTOL-MYERS SQUIBB COMPANY (US) 1997-07-16 EP claimed
EP-0584001-B1 Use of taxol for the manufacture of a medicament for the treatment of cancer BRISTOL MYERS SQUIBB CO (US) 1997-05-14 EP claimed
EP-0596958-A1 ADHESIVE STICK MADE FROM STARCH ETHERS. HENKEL KGAA (DE) 1994-05-18 EP claimed
EP-0584001-A1 Products containing taxol for use in cancer therapy BRISTOL-MYERS SQUIBB COMPANY (US) 1994-02-23 EP claimed
WO-1993003109-A2 ADHESIVE STICK MADE FROM STARCH ETHERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1993-02-18 WO claimed
EP-0278297-A1 Adhesive stick Henkel Kommanditgesellschaft auf Aktien (DE) 1988-08-17 EP claimed
US-4728513-A HEAT TREATED FOR STORAGE STABILITY ZYMA SA (CH) 1988-03-01 US claimed
US-4256743-A PHENOTHIAZINES, ETHYLENEDIAMINES, INDENES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1981-03-17 US claimed
US-4104382-A (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4000302-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-12-28 US claimed