Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethindene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 20/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 19/20 | 0.82 |
| ▸ | CHRM4 | P08173 | 19/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 19/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 19/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.82 |
| ▸ | DRD1 | P21728 | 1/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethindene SCHEMBL29887834 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL1972832 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29455130 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL19284560 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL30436315 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| (S)-(+)-Dimethindene SCHEMBL30910954 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29676184 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL18759 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL28142887 | 0.81 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6276908 | 0.78 | HRH1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 977 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025026525-A1 | HETEROCYCLIC COMPOUNDS AS PHYSIOLOGICAL COOLANTS | SYMRISE AG (DE) | 2025-02-06 | — | — | WO | claimed |
| EP-4469439-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2024-12-04 | — | — | EP | claimed |
| EP-3689324-B1 | NEW COOLING AGENTS AND PREPARATIONS COMPRISING THEM | SYMRISE AG (DE) | 2024-11-20 | — | — | EP | claimed |
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | SYMRISE AG (DE) | 2024-01-04 | — | — | US | claimed |
| EP-4247791-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2023-09-27 | — | — | EP | claimed |
| WO-2023143741-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2023144326-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2022105986-A1 | NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2022-05-27 | — | — | WO | claimed |
| WO-2022106452-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2022-05-27 | — | — | WO | claimed |
| EP-3689324-A1 | NEW COOLING AGENTS AND PREPARATIONS COMPRISING THEM | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| US-20050074414-A1 | Penetrating pharmaceutical foam | FOAMIX LTD. (IL) | 2005-04-07 | — | — | US | claimed |
| US-20050069566-A1 | Alcohol-free drug or cosmetics carrier mixture of water, hydrophobic solvent, surfactant and gelling agent; oil in water emulsions | FOAMIX LTD. (IL) | 2005-03-31 | — | — | US | claimed |
| WO-2005018530-A2 | PENETRATING PHARMACEUTICAL FOAM | FOAMIX LTD. (US) | 2005-03-03 | — | — | WO | claimed |
| WO-2005011567-A2 | FOAM CARRIER CONTAINING AMPHIPHILIC COPOLYMERIC GELLING AGENT | FOAMIX LTD. (US) | 2005-02-10 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0783885-A2 | Use of taxol for the manufacture of a medicament for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-16 | — | — | EP | claimed |
| EP-0783886-A2 | Use of taxol for the manufacture of a medicament for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-16 | — | — | EP | claimed |
| EP-0584001-B1 | Use of taxol for the manufacture of a medicament for the treatment of cancer | BRISTOL MYERS SQUIBB CO (US) | 1997-05-14 | — | — | EP | claimed |
| EP-0584001-A1 | Products containing taxol for use in cancer therapy | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-02-23 | — | — | EP | claimed |
| US-4256743-A | PHENOTHIAZINES, ETHYLENEDIAMINES, INDENES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1981-03-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | TTPA, TREH, TAS2R45 | HRH1 3757/4885CHRM1 3278/4885CHRM2 2762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.