Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethindene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 20/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 19/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 19/20 | 0.76 |
| ▸ | CHRM5 | P08912 | 19/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 19/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.76 |
| ▸ | DRD1 | P21728 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethindene SCHEMBL29676184 | 0.87 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| (S)-(+)-Dimethindene SCHEMBL30910954 | 0.87 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL18759 | 0.87 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL30436315 | 0.87 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL19284560 | 0.87 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29455130 | 0.81 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29887834 | 0.81 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL1972832 | 0.81 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL359490 | 0.81 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6276908 | 0.75 | HRH1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |