Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (S)-(+)-Dimethindene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 20/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 19/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 19/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 19/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 19/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethindene SCHEMBL18759 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL30436315 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29676184 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL19284560 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL1972832 | 0.90 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29455130 | 0.90 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL359490 | 0.90 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29887834 | 0.90 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL28142887 | 0.87 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6276908 | 0.87 | HRH1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4637708-A2 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | Novaliq GmbH (DE) | 2025-10-29 | — | — | EP | claimed |
| WO-2024133913-A9 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | NOVALIQ GMBH (DE) | 2025-03-20 | — | — | WO | claimed |
| WO-2024133913-A2 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | NOVALIQ GMBH (DE) | 2024-06-27 | — | — | WO | claimed |
| EP-4637708-A2 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | Novaliq GmbH (DE) | 2025-10-29 | — | — | EP | disclosed |
| US-20250288591-A1 | TRIMEPRAZINE FOR USE IN TREATING TRIGEMINAL NEURALGIA AND FOR REDUCING PAIN RELATED THERETO | UNDAUNTED BIO, INC. (US) | 2025-09-18 | — | — | US | disclosed |
| US-20250134903-A1 | COMPOSITIONS AND METHODS FOR TREATING PAIN | UNDAUNTED BIO, INC. (US) | 2025-05-01 | — | — | US | disclosed |
| WO-2024133913-A9 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | NOVALIQ GMBH (DE) | 2025-03-20 | — | — | WO | disclosed |
| WO-2024133913-A2 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | NOVALIQ GMBH (DE) | 2024-06-27 | — | — | WO | disclosed |