Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethindene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 20/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 19/20 | 0.82 |
| ▸ | CHRM4 | P08173 | 19/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 19/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 19/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.82 |
| ▸ | DRD1 | P21728 | 1/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethindene SCHEMBL29887834 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL1972832 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL359490 | 1.00 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL19284560 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL30436315 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| (S)-(+)-Dimethindene SCHEMBL30910954 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL29676184 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL18759 | 0.90 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Dimethindene SCHEMBL28142887 | 0.81 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6276908 | 0.78 | HRH1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119979473-A | Method for forming bovine primordial germ cell-like cells by differentiating bovine iPSCs | 内蒙古大学 | 2025-05-13 | — | — | CN | claimed |
| CN-118345027-B | 3D suspension culture method capable of maintaining characteristics of expanded pluripotent stem cells | 深圳市北科源细胞科技有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119193473-A | Method for obtaining expansile pluripotent stem cells from peripheral blood mononuclear cells by reprogramming | 深圳市北科源细胞科技有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118345027-A | 3D suspension culture method capable of maintaining characteristics of expanded pluripotent stem cells | 深圳市北科源细胞科技有限公司 | 2024-07-16 | — | — | CN | claimed |
| EP-3334820-B1 | INDUCED EXTENDED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USING | BEIHAO STEM CELL AND REGENERATIVE MEDICINE RES INSTITUTE CO LTD (CN) | 2024-05-15 | — | — | EP | claimed |
| CN-117736974-A | Application of DAPT in maintaining multipotency of expanded multipotential stem cells and improving proliferation capacity of multipotential stem cells | 呈诺再生医学科技(北京)有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-116355837-A | EPSC suspension culture and neural stem cell differentiation method | 呈诺再生医学科技(北京)有限公司 | 2023-06-30 | — | — | CN | claimed |
| US-20260132373-A1 | BOVINE BLASTOCYST LIKE STRUCTURES AND USES THEREOF | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2026-05-14 | — | — | US | disclosed |
| US-12467917-B2 | Reconstructing human early embryogenesis in vitro with pluripotent stem cells | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2025-11-11 | — | — | US | disclosed |
| EP-4569013-A1 | BOVINE BLASTOCYST LIKE STRUCTURES AND USES THEREOF | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (US) | 2025-06-18 | — | — | EP | disclosed |
| US-20250188422-A1 | INDUCED TOTIPOTENT POTENTIAL STEM CELLS, METHODS OF MAKING AND USING | PEKING UNIVERSITY (CN) | 2025-06-12 | — | — | US | disclosed |
| CN-119979473-A | Method for forming bovine primordial germ cell-like cells by differentiating bovine iPSCs | 内蒙古大学 | 2025-05-13 | — | — | CN | disclosed |
| CN-119913110-A | Method for producing high-proportion chimeric living monkey by utilizing embryonic stem cells | 中国科学院脑科学与智能技术卓越创新中心 | 2025-05-02 | — | — | CN | disclosed |
| US-20230073534-A1 | MODULATING TLR/NF-KB AND P53 SIGNALING PATHWAYS TO ENHANCE INTERSPECIES CHIMERISM BETWEEN EVOLUTIONARYILY DISTANT SPECIES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-03-09 | — | — | US | disclosed |
| US-20220389376-A1 | Methods for Reprogramming Cells | NANTES UNIVERSITE (FR) | 2022-12-08 | — | — | US | disclosed |
| WO-2022242455-A1 | METHOD FOR INDUCING DIFFERENTIATION OF EXTENDED PLURIPOTENT STEM CELLS INTO CARDIOMYOCYTES AND APPLICATION THEREOF | 湖北大学 | 2022-11-24 | — | — | WO | disclosed |
| US-20220308041-A1 | RECONSTRUCTING HUMAN EARLY EMBRYOGENESIS IN VITRO WITH PLURIPOTENT STEM CELLS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-09-29 | — | — | US | disclosed |
| EP-4058565-A1 | METHODS FOR REPROGRAMMING CELLS | Monash University (AU) | 2022-09-21 | — | — | EP | disclosed |
| US-20220177862-A1 | Precise Gene Activation Via Novel Designed Proteins Mediating Epigenetic Remodeling | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-09 | — | — | US | disclosed |
| US-20220090023-A1 | METHODS FOR REGULATING POTENCY OF PLURIPOTENT STEM CELLS AND APPLICATIONS THEREOF | ACADEMIA SINICA (TW) | 2022-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132373-A1 | BOVINE BLASTOCYST LIKE STRUCTURES AND USES THEREOF | STAT3, SMAD2, LIFR | HRH1 1967/4885CHRM1 4553/4885CHRM2 4290/4885 |
| US-20220090023-A1 | METHODS FOR REGULATING POTENCY OF PLURIPOTENT STEM CELLS AND APPLICATIONS THEREOF | CDYL, ZFX, CDYL2 | HRH1 4766/4885CHRM1 4776/4885CHRM2 4788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.