Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16044787 | 0.92 | ADORA2B (0.38) | CSNK1DCSNK1EMAPK13ADORA2BTSHR | |
| Trifluoroacetic Acid SCHEMBL18759462 | 0.91 | PDE10A (0.40) | PDE10ACSNK1DKDRPLK4AURKA | |
| Trifluoroacetic Acid SCHEMBL18759464 | 0.89 | ADORA3 (0.42) | PDE10ACSNK1DKDRPLK4AURKA | |
| Trifluoroacetic Acid SCHEMBL18759443 | 0.88 | PDE10A (0.44) | PDE10ACSNK1DCSNK1EKDRMAPK13 | |
| Trifluoroacetic Acid SCHEMBL18759448 | 0.87 | PDE10A (0.38) | PDE10AKDRMAPK13FYNTSHR | |
| Trifluoroacetic Acid SCHEMBL18759412 | 0.86 | PDE10A (0.44) | PDE10ACSNK1DCSNK1EKDRPLK4 | |
| Trifluoroacetic Acid SCHEMBL18759465 | 0.86 | PDE10A (0.44) | PDE10ACSNK1DKDRPLK4AURKA | |
| Trifluoroacetic Acid SCHEMBL18759421 | 0.86 | PDE10A (0.44) | PDE10ACSNK1DCSNK1EKDRPLK4 | |
| Trifluoroacetic Acid SCHEMBL18759474 | 0.86 | PDE10A (0.44) | PDE10AKDRCSF1RFGFR1FLT1 | |
| Trifluoroacetic Acid SCHEMBL18759418 | 0.86 | PDE10A (0.44) | PDE10AKDRPLK4AURKAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970328-B1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-04-26 | — | — | EP | disclosed |