Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274381 | 0.82 | MAPT (0.51) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL29942690 | 0.82 | HDAC4 (0.39) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL14088919 | 0.82 | MAPT (0.51) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL23752855 | 0.82 | HDAC4 (0.39) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL14904519 | 0.82 | NFE2L2 (0.54) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL23752854 | 0.82 | HDAC4 (0.39) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL13459745 | 0.80 | NPC1 (0.50) | NPC1CASP3SENP8SENP7SENP6 | |
| SCHEMBL8274382 | 0.79 | SRC (0.47) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL5433181 | 0.79 | HDAC8 (0.45) | HDAC4HDAC2HDAC8NPC1CASP3 | |
| SCHEMBL349422 | 0.77 | HDAC8 (0.44) | HDAC4HDAC2HDAC8NPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066742-A1 | BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE | JORTAN PHARMACEUTICALS INC. (US) | 2017-04-20 | — | — | WO | disclosed |