Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768559 | 0.84 | GSK3B (0.60) | NPC1RAB9ALMNA | |
| SCHEMBL18767324 | 0.83 | NPC1 (0.52) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL18768365 | 0.83 | AKR1C3 (0.52) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL18767964 | 0.80 | SLC6A2 (0.59) | HPGDALDH1A1HSD17B10AKR1C3KDM4E | |
| SCHEMBL18768629 | 0.79 | GSK3B (0.59) | KMT2AMEN1LMNA | |
| SCHEMBL18767961 | 0.79 | AKR1C3 (0.57) | NPC1RAB9AKMT2AMEN1MTNR1A | |
| SCHEMBL14056716 | 0.79 | TGM2 (0.60) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL177033 | 0.79 | NAMPT (0.75) | NAMPT | |
| SCHEMBL6885051 | 0.78 | KDM4E (0.67) | HPGDALDH1A1HSD17B10AKR1C3KDM4E | |
| SCHEMBL18768635 | 0.78 | KMT2A (0.51) | NPC1RAB9AKMT2AMEN1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |