Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768559 | 0.84 | GSK3B (0.60) | NPC1RAB9ASLC6A2SLC6A4DRD2 | |
| SCHEMBL18767313 | 0.83 | NPC1 (0.52) | NPC1RAB9AMTNR1AMTNR1BAKR1C3 | |
| SCHEMBL18768365 | 0.83 | AKR1C3 (0.52) | NPC1RAB9AMTNR1AMTNR1BAKR1C3 | |
| SCHEMBL18767961 | 0.81 | AKR1C3 (0.57) | NPC1RAB9AMTNR1AMTNR1BAKR1C3 | |
| SCHEMBL18767964 | 0.80 | SLC6A2 (0.59) | AKR1C3KDM4EHPGDHSD17B10SLC6A2 | |
| SCHEMBL18768629 | 0.79 | GSK3B (0.59) | KMT2ASLC6A2SLC6A4MEN1DRD2 | |
| SCHEMBL6885051 | 0.78 | KDM4E (0.67) | AKR1C3KDM4EHPGDHSD17B10DRD3 | |
| SCHEMBL18768635 | 0.78 | KMT2A (0.51) | NPC1RAB9AMTNR1AMTNR1BAKR1C3 | |
| SCHEMBL18768552 | 0.77 | ACHE (0.56) | SLC6A2SLC6A4DRD3HTR1ADRD2 | |
| SCHEMBL6883734 | 0.76 | KDM4E (0.68) | AKR1C3KDM4EHPGDHSD17B10DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |