Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 6/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768629 | 0.91 | GSK3B (0.59) | GSK3BDRD4DRD2ACHEBACE1 | |
| SCHEMBL18768573 | 0.89 | SLC6A2 (0.66) | GSK3BDRD4DRD2ACHEBACE1 | |
| SCHEMBL18768420 | 0.88 | LMNA (0.57) | DRD4DRD2ACHEBACE1FAAH | |
| SCHEMBL18768364 | 0.87 | LMNA (0.69) | DRD4DRD2ACHEBACE1LMNA | |
| SCHEMBL18768365 | 0.87 | AKR1C3 (0.52) | LMNASLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL18768552 | 0.85 | ACHE (0.56) | DRD4DRD2ACHEBACE1LMNA | |
| SCHEMBL18767313 | 0.84 | NPC1 (0.52) | LMNANPC1RAB9A | |
| SCHEMBL18767324 | 0.84 | NPC1 (0.52) | GSK3BDRD2SLC6A2SLC6A4NPC1 | |
| SCHEMBL18768417 | 0.84 | SLC6A2 (0.57) | DRD4DRD2ACHEBACE1LMNA | |
| SCHEMBL18768425 | 0.82 | MEN1 (0.51) | DRD4DRD2ACHEBACE1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |