Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768573 | 0.92 | SLC6A2 (0.66) | SLC6A2SLC6A4TP53HDAC3HDAC4 | |
| SCHEMBL18768420 | 0.91 | LMNA (0.57) | SLC6A2SLC6A4TP53HDAC6ACHE | |
| SCHEMBL18768361 | 0.89 | LMNA (0.57) | SLC6A2SLC6A4TP53HDAC3HDAC4 | |
| SCHEMBL18768364 | 0.86 | LMNA (0.69) | SLC6A2SLC6A4TP53MAPTHDAC3 | |
| SCHEMBL18768629 | 0.86 | GSK3B (0.59) | SLC6A2SLC6A4TP53ACHEBACE1 | |
| SCHEMBL18768440 | 0.84 | TP53 (0.70) | SLC6A2SLC6A4TP53LMNADRD2 | |
| SCHEMBL18768559 | 0.84 | GSK3B (0.60) | SLC6A2SLC6A4TP53ACHEBACE1 | |
| SCHEMBL18768421 | 0.80 | KMT2A (0.58) | SLC6A2SLC6A4TP53SMN1; SMN2ACHE | |
| SCHEMBL6885051 | 0.80 | KDM4E (0.67) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18767964 | 0.79 | SLC6A2 (0.59) | SLC6A2SLC6A4MAPK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |