Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768573 | 0.92 | SLC6A2 (0.66) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768420 | 0.91 | LMNA (0.57) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768361 | 0.90 | LMNA (0.57) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768559 | 0.87 | GSK3B (0.60) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768417 | 0.86 | SLC6A2 (0.57) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768421 | 0.86 | KMT2A (0.58) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768440 | 0.84 | TP53 (0.70) | LMNATP53SLC6A2SLC6A4KDM4E | |
| SCHEMBL18768629 | 0.82 | GSK3B (0.59) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768552 | 0.82 | ACHE (0.56) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL6885051 | 0.81 | KDM4E (0.67) | HDAC6KDM4EHSD17B10HPGDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |