Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | CCR2 | P41597 | 4/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768573 | 0.93 | SLC6A2 (0.66) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768417 | 0.91 | SLC6A2 (0.57) | LMNATP53SLC6A2SLC6A4KCNH2 | |
| SCHEMBL18768364 | 0.91 | LMNA (0.69) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768559 | 0.88 | GSK3B (0.60) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768440 | 0.87 | TP53 (0.70) | LMNATP53SLC6A2SLC6A4KDM4E | |
| SCHEMBL18768361 | 0.85 | LMNA (0.57) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768421 | 0.83 | KMT2A (0.58) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL18768629 | 0.83 | GSK3B (0.59) | LMNATP53SLC6A2SLC6A4ACHE | |
| SCHEMBL6885051 | 0.82 | KDM4E (0.67) | HDAC6KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL18767964 | 0.82 | SLC6A2 (0.59) | SLC6A2SLC6A4KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |