Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770184 | 0.83 | ACLY (0.42) | ACLYITGAVBCAT2ALDH1A1NPSR1 | |
| SCHEMBL18770158 | 0.81 | ACLY (0.41) | ACLYITGAVBCAT2LOXHSD11B1 | |
| SCHEMBL20664199 | 0.76 | ACLY (0.38) | ACLYITGAVBCAT2LOXMEN1 | |
| SCHEMBL15953544 | 0.76 | ITGAV (0.43) | ACLYITGAVBCAT2MEN1KMT2A | |
| SCHEMBL18770177 | 0.76 | ITGAV (0.40) | ACLYITGAVBCAT2LOXHSD11B1 | |
| SCHEMBL18770145 | 0.76 | ITGAV (0.40) | ACLYITGAVBCAT2LOXMEN1 | |
| SCHEMBL1926122 | 0.76 | ITGAV (0.40) | ACLYITGAVBCAT2MEN1KMT2A | |
| SCHEMBL15953542 | 0.75 | BCAT2 (0.45) | ACLYITGAVBCAT2MEN1KMT2A | |
| SCHEMBL1927897 | 0.75 | ITGAV (0.42) | ACLYITGAVBCAT2MEN1KMT2A | |
| SCHEMBL14627755 | 0.75 | CA1 (0.59) | MEN1KMT2AALDH1A1ARSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365325-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2018-08-29 | — | — | EP | claimed |
| CN-108368038-A | N- hydroxysulfonamide amine derivatives as nitroxyl donors | 卡尔迪奥克斯尔制药公司 | 2018-08-03 | — | — | CN | claimed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | claimed |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY | 2018-10-25 | — | — | US | disclosed |
| EP-3365325-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2018-08-29 | — | — | EP | disclosed |
| CN-108368038-A | N- hydroxysulfonamide amine derivatives as nitroxyl donors | 卡尔迪奥克斯尔制药公司 | 2018-08-03 | — | — | CN | disclosed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | TNNI3, TNNT2, TNNC1 | ACLY 82/4885ITGAV 4450/4885BCAT2 2691/4885 |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | TNNI3, TNNT2, TNNC1 | ACLY 82/4885ITGAV 4450/4885BCAT2 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.