Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 1/20 | 0.63 |
| ▸ | APP | P05067 | 9/20 | 0.59 |
| ▸ | CA12 | O43570 | 6/20 | 0.59 |
| ▸ | CA1 | P00915 | 6/20 | 0.59 |
| ▸ | CA2 | P00918 | 6/20 | 0.59 |
| ▸ | CA6 | P23280 | 6/20 | 0.59 |
| ▸ | CA7 | P43166 | 6/20 | 0.59 |
| ▸ | CA9 | Q16790 | 6/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.59 |
| ▸ | CA5A | P35218 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770125 | 0.92 | APP (0.71) | AQP1APPCA12CA1CA2 | |
| SCHEMBL230206 | 0.79 | CA12 (0.73) | AQP1APPCA12CA1CA2 | |
| SCHEMBL29436046 | 0.79 | CA1 (0.79) | AQP1APPCA12CA1CA2 | |
| SCHEMBL12418656 | 0.78 | AQP1 (0.82) | AQP1APPCA12CA1CA2 | |
| SCHEMBL18770180 | 0.78 | NPC1 (0.54) | CA12CA1CA2CA6CA7 | |
| SCHEMBL12418652 | 0.77 | AQP1 (1.00) | AQP1APPCA12CA1CA2 | |
| SCHEMBL12418662 | 0.76 | CA12 (0.68) | AQP1APPCA12CA1CA2 | |
| SCHEMBL22852419 | 0.76 | APP (0.82) | AQP1APPCA12CA1CA2 | |
| SCHEMBL22852414 | 0.76 | APP (0.74) | AQP1APPCA12CA1CA2 | |
| SCHEMBL10837475 | 0.76 | CA12 (0.82) | AQP1APPCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365325-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2018-08-29 | — | — | EP | claimed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | claimed |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY | 2018-10-25 | — | — | US | disclosed |
| EP-3365325-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | TNNI3, TNNT2, TNNC1 | AQP1 2968/4885APP 4155/4885CA12 3219/4885 |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | TNNI3, TNNT2, TNNC1 | AQP1 2968/4885APP 4155/4885CA12 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.