SCHEMBL230206

SCHEMBL230206

NS(=O)(=O)c1cc(C(=O)OCc2ccccc2)c(NCc2ccco2)cc1Cl

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 7/20 0.73
CA1 P00915 7/20 0.73
CA2 P00918 7/20 0.73
CA9 Q16790 7/20 0.73
CA6 P23280 6/20 0.73
CA7 P43166 6/20 0.73
CA14 Q9ULX7 6/20 0.73
CA5B Q9Y2D0 6/20 0.73
CA5A P35218 5/20 0.73
CISD1 Q9NZ45 4/20 0.73
ALDH1A1 P00352 1/20 0.73
HTR1A P08908 1/20 0.73
CA4 P22748 1/20 0.73
HSD11B1 P28845 1/20 0.73
SLC10A1 Q14973 1/20 0.73
GPR35 Q9HC97 1/20 0.73
ABCG2 Q9UNQ0 1/20 0.73
AQP1 P29972 1/20 0.66
APP P05067 9/20 0.60
TEX264 Q9Y6I9 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12418662 0.93 CA12 (0.68) CA12CA1CA2CA9CA6
SCHEMBL228969 0.92 CA12 (0.72) CA12CA1CA2CA9CA6
SCHEMBL22971336 0.91 CA12 (0.66) CA12CA1CA2CA9CA6
SCHEMBL230438 0.90 CA12 (0.65) CA12CA1CA2CA9CA6
SCHEMBL229100 0.89 CA12 (0.68) CA12CA1CA2CA9CA6
SCHEMBL4412903 0.89 CISD1 (0.76) CA12CA1CA2CA9CA6
SCHEMBL2949798 0.88 CA12 (0.76) CA12CA1CA2CA9CA6
SCHEMBL5153664 0.87 CA12 (0.74) CA12CA1CA2CA9CA6
SCHEMBL21019469 0.87 CA12 (0.74) CA12CA1CA2CA9CA6
SCHEMBL231262 0.87 CA12 (0.74) CA12CA1CA2CA9CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210137875-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM OTOLANUM AG (CH) 2021-05-13 US claimed
US-20180360797-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) 2018-12-20 US claimed
WO-2017042314-A1 METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF POST-TRAUMATIC EPILEPSIES INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-03-16 WO claimed
US-20160271098-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) 2016-09-22 US claimed
US-20150044200-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM OTOLANUM AG (CH) 2015-02-12 US claimed
EP-2790686-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM Auris Medical AG (CH) 2014-10-22 EP claimed
WO-2013087090-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM AURIS MEDICAL AG (CH) 2013-06-20 WO claimed
US-20120234721-A1 DIURETIC AND DIURETIC-LIKE COMPOUND ANALOGS NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-09-20 US claimed
US-20120108640-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-05-03 US claimed
US-20090215754-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NEUROTHERAPEUTICS PHARMA, INC. 2009-08-27 US claimed
EP-1874286-A4 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS NEUROTHERAPEUTICS PHARMA INC (US) 2009-07-01 EP claimed
EP-1951702-A2 DIURETIC-LIKE COMPOUND ANALOGS USEFUL FOR REGULATION OF CENTRAL NERVOUS SYSTEM DISORDERS NeuroTherapeutics Pharma, Inc. (US) 2008-08-06 EP claimed
EP-1937242-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NeuroTherapeutics Pharma, Inc. (US) 2008-07-02 EP claimed
EP-1874286-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS Neurotherapeutics Pharma LLC (US) 2008-01-09 EP claimed
US-20070149526-A1 Diuretic and diuretic-like compound analogs NEUROTHERAPEUTICS PHARMA, L.L.C. 2007-06-28 US claimed
WO-2007047447-A2 DIURETIC-LIKE COMPOUND ANALOGS USEFUL FOR REGULATION OF CENTRAL NERVOUS SYSTEM DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2007-04-26 WO claimed
WO-2007047698-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2007-04-26 WO claimed
WO-2006110187-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS NEUROTHERAPEUTICS PHARMA LLC (US) 2006-10-19 WO claimed
US-20060089350-A1 Methods and compositions for the treatment of neuropsychiatric disorders NEUROTHERAPEUTICS PHARMA LLC (US) 2006-04-27 US claimed
US-20240009153-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROPRO THERAPEUTICS, INC. 2024-01-11 US disclosed
US-20220071935-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROPRO THERAPEUTICS, INC. 2022-03-10 US disclosed
US-20210137875-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM OTOLANUM AG (CH) 2021-05-13 US disclosed
EP-2790686-B1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM Zilentin AG (CH) 2021-03-10 EP disclosed
US-10709682-B2 Treatment of tinnitus through modulation of chloride co-transporter NKCC1 in the auditory system OTOLANUM AG (CH) 2020-07-14 US disclosed
US-20190151263-A1 BUMETANIDE ANALGOS, COMPOSITIONS, AND METHODS OF USE NEUROPRO THERAPEUTICS INC (US) 2019-05-23 US disclosed
EP-3004353-B1 BUMETANIDE FOR TREATING NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES B & A THERAPEUTICS INMED (FR) 2019-04-10 EP disclosed
US-10201507-B2 Modulators of intracellular chloride concentration for treating fragile X syndrome NEUROCHLORE (FR) 2019-02-12 US disclosed
EP-3083959-B1 INHIBITORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING DOWN SYNDROME FONDAZIONE ST ITALIANO TECNOLOGIA (IT) 2019-02-06 EP disclosed
US-20180360797-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) 2018-12-20 US disclosed
US-9974763-B2 Modulators of intracellular chloride concentration for treating neurodegenerative diseases with Parkinsonian Syndromes B&A THERAPEUTICS (FR) 2018-05-22 US disclosed
US-9822368-B2 Modulators of intracellular chloride concentration for treating down syndrome FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2017-11-21 US disclosed
US-20170246131-A1 BUMETANIDE ANALOGS, COMPOSITIONS, AND METHODS OF USE NEUROPRO THERAPEUTICS INC (US) 2017-08-31 US disclosed
US-9682928-B2 Bumetanide analogs, compositions and methods of use NEUROPRO THERAPEUTICS, INC. (US) 2017-06-20 US disclosed
EP-2523661-B1 NKCC INHIBITORS FOR THE TREATMENT OF AUTISM INSERM (INSTITUT NAT DE LA SANTÉ ET DE LA RECH MÉDICALE) (FR) 2017-05-10 EP disclosed
WO-2017042314-A1 METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF POST-TRAUMATIC EPILEPSIES INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-03-16 WO disclosed
US-9592214-B2 Compounds for the treatment of autism in a baby child INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2017-03-14 US disclosed
US-20160312229-A1 Modulators of Intracellular Chloride Concentration for Treating Down Syndrome FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2016-10-27 US disclosed
EP-3083959-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING DOWN SYNDROME Fondazione Istituto Italiano Di Tecnologia (IT) 2016-10-26 EP disclosed
US-20160271098-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) 2016-09-22 US disclosed
US-9415028-B2 Compounds for the treatment of autism INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2016-08-16 US disclosed
US-20160106693-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES NANTES UNIVERSITE (FR) 2016-04-21 US disclosed
EP-3004353-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES B & A Therapeutics INMED (FR) 2016-04-13 EP disclosed
US-9248131-B2 Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2016-02-02 US disclosed
US-20150335600-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING FRAGILE X SYNDROME INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2015-11-26 US disclosed
EP-2919769-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING FRAGILE X SYNDROME Neurochlore (FR) 2015-09-23 EP disclosed
US-20150224108-A1 AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE UNIV ARIZONA STATE (US) 2015-08-13 US disclosed
WO-2015091857-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING DOWN SYNDROME FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2015-06-25 WO disclosed
US-20150080350-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROPRO THERAPEUTICS INC. 2015-03-19 US disclosed
US-20150044200-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM OTOLANUM AG (CH) 2015-02-12 US disclosed
WO-2014191471-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES NEUROCHLORE (FR) 2014-12-04 WO disclosed
EP-2808391-A1 Modulators of intracellular chloride concentration for treating neurodegenerative diseases with parkinsonian syndromes Neurochlore (FR) 2014-12-03 EP disclosed
EP-2790686-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM Auris Medical AG (CH) 2014-10-22 EP disclosed
US-8835491-B2 Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2014-09-16 US disclosed
WO-2014076235-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING FRAGILE X SYNDROME NEUROCHLORE (FR) 2014-05-22 WO disclosed
EP-2732815-A1 Modulators of intracellular chloride concentration for treating fragile X syndrome Neurochlore (FR) 2014-05-21 EP disclosed
US-20140080910-A1 COMPOUNDS FOR THE TREATMENT OF AUTISM IN A BABY CHILD NEUROCHLORE (FR) 2014-03-20 US disclosed
WO-2013087090-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM AURIS MEDICAL AG (CH) 2013-06-20 WO disclosed
US-20130022622-A1 COMPOUNDS FOR THE TREATMENT OF AUTISM CHU DE BREST (FR) 2013-01-24 US disclosed
EP-2523661-A1 COMPOUNDS FOR THE TREATMENT OF AUTISM INSERM - Institut National de la Santé et de la Recherche Médicale (FR) 2012-11-21 EP disclosed
US-20120252894-A1 COMPOUNDS FOR ALLEVIATING PAIN AND STRESS IN FETUS AND NEWBORN INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCH MEDICALE (INSERM) (FR) 2012-10-04 US disclosed
US-20120234721-A1 DIURETIC AND DIURETIC-LIKE COMPOUND ANALOGS NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-09-20 US disclosed
US-20120108640-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-05-03 US disclosed
US-20120004225-A1 BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-01-05 US disclosed
EP-2389371-A2 BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE Neurotherapeutics Pharma, Inc. (US) 2011-11-30 EP disclosed
US-8008283-B2 Methods and compositions for the treatment of neuropsychiatric disorders NEUROTHERAPEUTICS PHARMA, INC. (US) 2011-08-30 US disclosed
WO-2011086126-A1 COMPOUNDS FOR THE TREATMENT OF AUTISM INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2011-07-21 WO disclosed
US-20110172195-A1 AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) 2011-07-14 US disclosed
US-7906555-B2 Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2011-03-15 US disclosed
WO-2010085352-A2 BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROTHERAPEUTICS PHARMA, INC. (US) 2010-07-29 WO disclosed
US-20090215754-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NEUROTHERAPEUTICS PHARMA, INC. 2009-08-27 US disclosed
EP-1874286-A4 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS NEUROTHERAPEUTICS PHARMA INC (US) 2009-07-01 EP disclosed
US-20080221169-A1 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) 2008-09-11 US disclosed
US-20080221169-A1 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer ARIZONA BOARD OF REG. ON BEHALF OF THE UNIV. OF AZ (US) 2008-09-11 US disclosed
EP-1951702-A2 DIURETIC-LIKE COMPOUND ANALOGS USEFUL FOR REGULATION OF CENTRAL NERVOUS SYSTEM DISORDERS NeuroTherapeutics Pharma, Inc. (US) 2008-08-06 EP disclosed
EP-1937242-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NeuroTherapeutics Pharma, Inc. (US) 2008-07-02 EP disclosed
EP-1874286-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS Neurotherapeutics Pharma LLC (US) 2008-01-09 EP disclosed
US-20070149526-A1 Diuretic and diuretic-like compound analogs NEUROTHERAPEUTICS PHARMA, L.L.C. 2007-06-28 US disclosed
WO-2007047447-A2 DIURETIC-LIKE COMPOUND ANALOGS USEFUL FOR REGULATION OF CENTRAL NERVOUS SYSTEM DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2007-04-26 WO disclosed
WO-2007047698-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS NEUROTHERAPEUTICS PHARMA, INC. (US) 2007-04-26 WO disclosed
WO-2006110187-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANXIETY DISORDERS NEUROTHERAPEUTICS PHARMA LLC (US) 2006-10-19 WO disclosed
US-20060089350-A1 Methods and compositions for the treatment of neuropsychiatric disorders NEUROTHERAPEUTICS PHARMA LLC (US) 2006-04-27 US disclosed
US-20060089350-A1 Methods and compositions for the treatment of neuropsychiatric disorders NEUROTHERAPEUTICS PHARMA LLC (US) 2006-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (24 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160312229-A1 Modulators of Intracellular Chloride Concentration for Treating Down Syndrome SLC8B1, SLC6A1, SLC6A12 CA12 4590/4885CA1 3832/4885CA2 302/4885
US-20180360797-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM SLC6A1, SLC6A11, SLC6A13 CA12 1273/4885CA1 1240/4885CA2 209/4885
US-20120234721-A1 DIURETIC AND DIURETIC-LIKE COMPOUND ANALOGS AQP4, AVPR2, AQP1 CA12 1656/4885CA1 559/4885CA2 708/4885
US-20160106693-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES SLC6A1, SLC18A3, SLC8B1 CA12 4248/4885CA1 3471/4885CA2 573/4885
US-20080221169-A1 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels; brain trauma, head trauma, eye disorder, pulmonary disorder, lung disease, vascular disease, kidney disease, heavy metal toxicity, Alzheimer's disease, tumor, and cancer AQP4, AQP3, AQP1 CA12 372/4885CA1 223/4885CA2 12/4885
US-20240009153-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE SLC6A1, SLC6A13, SLC6A11 CA12 1338/4885CA1 988/4885CA2 489/4885
US-20160271098-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM SLC6A1, SLC6A11, SLC6A13 CA12 1146/4885CA1 1161/4885CA2 209/4885
US-20150335600-A1 MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR TREATING FRAGILE X SYNDROME SLC8B1, SLC6A1, SLC8A1 CA12 4639/4885CA1 3796/4885CA2 924/4885
US-20060089350-A1 Methods and compositions for the treatment of neuropsychiatric disorders SLC1A2, SLC18A2, GRIN2C CA12 1092/4885CA1 490/4885CA2 308/4885
US-10201507-B2 Modulators of intracellular chloride concentration for treating fragile X syndrome SLC8B1, SLC6A1, SLC8A1 CA12 4639/4885CA1 3796/4885CA2 924/4885
US-20210137875-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM SLC6A1, SLC6A13, SLC6A11 CA12 1181/4885CA1 1024/4885CA2 256/4885
US-20150224108-A1 AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE AQP1, AQP4, AQP3 CA12 1649/4885CA1 1196/4885CA2 168/4885
US-20170246131-A1 BUMETANIDE ANALOGS, COMPOSITIONS, AND METHODS OF USE SLC6A1, SLC6A13, SLC6A11 CA12 1444/4885CA1 1022/4885CA2 471/4885
US-20220071935-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE SLC6A1, SLC6A13, SLC6A11 CA12 1338/4885CA1 988/4885CA2 489/4885
US-20190151263-A1 BUMETANIDE ANALGOS, COMPOSITIONS, AND METHODS OF USE SLC6A1, SLC6A11, SLC6A13 CA12 1049/4885CA1 701/4885CA2 388/4885
US-20120004225-A1 BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE ABCG2, ABCB1, TRPV1 CA12 2528/4885CA1 1755/4885CA2 1572/4885
US-20070149526-A1 Diuretic and diuretic-like compound analogs AQP4, AVPR2, AQP1 CA12 1656/4885CA1 559/4885CA2 708/4885
US-20090215754-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS SLC6A2, SLC1A2, SLC18A2 CA12 1302/4885CA1 847/4885CA2 408/4885
US-20120108640-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS SLC1A2, SLC18A2, GRIN2C CA12 1092/4885CA1 490/4885CA2 308/4885
US-20150080350-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE SLC6A1, SLC6A13, SLC6A11 CA12 2583/4885CA1 1762/4885CA2 1422/4885
US-20140080910-A1 COMPOUNDS FOR THE TREATMENT OF AUTISM IN A BABY CHILD SLC6A1, SLC6A11, SLC6A13 CA12 1027/4885CA1 608/4885CA2 665/4885
US-20110172195-A1 AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE AQP1, AQP4, AQP3 CA12 1649/4885CA1 1196/4885CA2 168/4885
US-10709682-B2 Treatment of tinnitus through modulation of chloride co-transporter NKCC1 in the auditory system SLC6A1, SLC6A11, SLC6A13 CA12 1270/4885CA1 1239/4885CA2 208/4885
US-20150044200-A1 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM SLC6A1, SLC6A11, SLC6A13 CA12 1270/4885CA1 1239/4885CA2 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.