Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 4/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701620 | 0.86 | TLR8 (0.57) | MEN1HSP90AA1KMT2ATLR8TLR7 | |
| SCHEMBL18772071 | 0.81 | TLR8 (0.46) | MEN1KMT2ATLR8TLR7ALDH1A1 | |
| SCHEMBL18772200 | 0.80 | TLR8 (0.50) | MEN1KMT2ATLR8TLR7ALDH1A1 | |
| SCHEMBL18772121 | 0.78 | TLR8 (0.52) | TLR8TLR7ALDH1A1HPGD | |
| SCHEMBL18772107 | 0.76 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL18771832 | 0.76 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL18772042 | 0.75 | TLR8 (0.49) | TLR8TLR7ALDH1A1MAPTHPGD | |
| SCHEMBL19265669 | 0.74 | TLR8 (0.49) | TLR8TLR7ALDH1A1PPARGJAK2 | |
| SCHEMBL1239899 | 0.73 | PARP10 (0.46) | MEN1KMT2ATLR8TLR7ALDH1A1 | |
| SCHEMBL18771925 | 0.73 | TLR8 (0.45) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3225623-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |