Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877938 | 0.90 | GPR88 (0.62) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL8609579 | 0.86 | NPC1 (0.65) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL3836213 | 0.82 | LMNA (0.71) | NPC1ALDH1A1LMNAKMT2ARAB9A | |
| SCHEMBL8389369 | 0.80 | NPC1 (0.71) | NPC1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL6881166 | 0.80 | GPR88 (0.72) | NPC1ALDH1A1RAB9AFFAR1HPGD | |
| SCHEMBL18772237 | 0.80 | GPR88 (0.72) | NPC1ALDH1A1RAB9AFFAR1HPGD | |
| SCHEMBL8081319 | 0.80 | FFAR1 (0.61) | ALDH1A1LMNAFFAR1HPGDGPR88 | |
| Iodomethane SCHEMBL8387414 | 0.79 | NPC1 (0.70) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL18772228 | 0.79 | GPR88 (0.72) | FFAR1GPR88CNR2 | |
| SCHEMBL5862101 | 0.78 | NPC1 (1.00) | NPC1ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486011-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |