Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 12/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18772234 | 0.90 | NPC1 (0.64) | GPR88NPC1LMNAALDH1A1MEN1 | |
| SCHEMBL8609579 | 0.84 | NPC1 (0.65) | NPC1LMNAALDH1A1MEN1MAPT | |
| SCHEMBL18772259 | 0.82 | GPR88 (0.80) | GPR88 | |
| SCHEMBL18772252 | 0.82 | GPR88 (0.80) | GPR88 | |
| SCHEMBL3836213 | 0.82 | LMNA (0.71) | NPC1POLBLMNAALDH1A1KMT2A | |
| SCHEMBL8072213 | 0.81 | PLA2G4B (0.51) | GPR88 | |
| SCHEMBL6880190 | 0.81 | GPR88 (0.73) | GPR88 | |
| SCHEMBL26216471 | 0.80 | GPR88 (0.72) | GPR88 | |
| SCHEMBL18772260 | 0.80 | GPR88 (0.74) | GPR88 | |
| SCHEMBL18772240 | 0.79 | GPR88 (0.61) | GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146816-A1 | 4-SUBSTITUTED-PHENYL ACETAMIDES AND ARYLUREAS AS AGONISTS FOR THE ORPHAN RECEPTOR GPR88 | RESEARCH TRIANGLE INSTITUTE (US) | 2023-08-03 | — | — | WO | disclosed |
| EP-2486011-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |
| WO-2011044225-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |