Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18772234 | 0.86 | NPC1 (0.64) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6877938 | 0.84 | GPR88 (0.62) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL8411536 | 0.83 | RAB9A (0.61) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL8608723 | 0.83 | HPGD (0.63) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL25046034 | 0.82 | ALDH1A1 (0.63) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL8389369 | 0.81 | NPC1 (0.71) | NPC1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL3836213 | 0.80 | LMNA (0.71) | NPC1ALDH1A1LMNAKMT2AL3MBTL1 | |
| Iodomethane SCHEMBL8387414 | 0.80 | NPC1 (0.70) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL2517711 | 0.80 | PPARG (0.58) | KMT2AMEN1MAPTALOX12L3MBTL1 | |
| SCHEMBL8559951 | 0.80 | LMNA (0.56) | ALDH1A1LMNAKMT2AHPGDHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5927283-A | TREATING DISEASES INVOLVING OXYGEN DEFICIENCY, IN WOUND HEALING, AND IN RESTORING OXYGEN AFFINITY OF STORED BLOOD. | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5731454-A | Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5705521-A | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1998-01-06 | — | — | US | disclosed |
| US-5677330-A | THERAPY HYPOXIA, HYPOTHERMIA, ISCHEMIC, WOUNDS, ULCERS, TISSUE TRANSPLANTS, SESPIS | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1997-10-14 | — | — | US | disclosed |