Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4273434 | 0.99 | ALDH1A1 (0.54) | ALDH1A1GAAGRIN2BHDAC6KIT | |
| SCHEMBL16380765 | 0.88 | ALDH1A1 (0.55) | ALDH1A1GAAGRIN2BEPHX2L3MBTL1 | |
| SCHEMBL7348167 | 0.88 | GRIN2B (0.54) | ALDH1A1GAAGRIN2BEPHX2L3MBTL1 | |
| SCHEMBL4702839 | 0.87 | ALDH1A1 (0.49) | ALDH1A1GAAGRIN2BHDAC6KIT | |
| Hydrochloric Acid SCHEMBL6172170 | 0.87 | GRIN2B (0.53) | ALDH1A1GAAGRIN2BEPHX2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4277098 | 0.86 | HDAC6 (0.48) | ALDH1A1GAAGRIN2BHDAC6KIT | |
| SCHEMBL3565908 | 0.85 | HDAC6 (0.47) | ALDH1A1GAAHDAC6KITBRAF | |
| SCHEMBL4267580 | 0.85 | MAPT (0.57) | ALDH1A1GAAHDAC6KITMAPT | |
| SCHEMBL13529185 | 0.84 | DDR1 (0.53) | ALDH1A1GAAHDAC6ADORA1KDM4E | |
| SCHEMBL4893579 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HDAC6KITEPHX2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834432-B2 | Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-12-05 | — | — | US | disclosed |
| US-20170349588-A1 | 1H-1,8-NAPHTHYRIDIN-2-ONES AS ANTI PROLIFERATIVE COMPOUNDS | NATCO PHARMA LIMITED (IN) | 2017-12-07 | — | — | US | disclosed |
| US-9765072-B2 | 1H-1,8-naphthyridin-2ones as anti proliferative compounds | NATCO PHARMA LIMITED (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170114057-A1 | 1H-1,8-NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS | NATCO PHARMA LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349588-A1 | 1H-1,8-NAPHTHYRIDIN-2-ONES AS ANTI PROLIFERATIVE COMPOUNDS | ABL1, MKI67, MCL1 | ALDH1A1 472/4885GAA 889/4885GRIN2B 3841/4885 |
| US-11834432-B2 | Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof | NOS2, NOS1, NOS3 | ALDH1A1 1897/4885GAA 1541/4885GRIN2B 1181/4885 |
| US-20170114057-A1 | 1H-1,8-NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS | ABL1, MKI67, ABL2 | ALDH1A1 390/4885GAA 857/4885GRIN2B 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.