Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15042290 | 0.82 | TDP1 (0.40) | ITGB3ITGA2BALDH1A1LMNAMAPT | |
| SCHEMBL16476750 | 0.82 | CTSC (0.46) | DPP4DPP8DPP7ITGB3ITGA2B | |
| SCHEMBL8650914 | 0.79 | MME (0.49) | — | |
| SCHEMBL30355295 | 0.79 | MME (0.49) | — | |
| SCHEMBL8648570 | 0.79 | MME (0.49) | — | |
| SCHEMBL29378709 | 0.79 | MME (0.49) | — | |
| SCHEMBL7825934 | 0.79 | MME (0.49) | — | |
| SCHEMBL10162444 | 0.79 | DPP4 (0.63) | DPP4DPP8LMNAMAPTDPP9 | |
| SCHEMBL23380925 | 0.78 | GNPAT (0.43) | DPP4DPP8DPP7CTRB1 | |
| SCHEMBL5881138 | 0.78 | NOD1 (0.48) | DPP4DPP8DPP7CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170304383-A1 | SMALL MOLECULE RAS INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2017-10-26 | — | — | US | disclosed |
| US-20170112896-A1 | SMALL MOLECULE RAC OR RHO INHIBITORS | NIH - DEITR | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112896-A1 | SMALL MOLECULE RAC OR RHO INHIBITORS | ARHGDIB, ARHGDIA, RHOT2 | DPP4 4768/4885DPP8 4221/4885DPP7 4130/4885 |
| US-20170304383-A1 | SMALL MOLECULE RAS INHIBITORS | KRAS, NRAS, HRAS | DPP4 3447/4885DPP8 2667/4885DPP7 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.