Abrine

Abrine

SCHEMBL18778

CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.70
ACE P12821 3/20 0.69
KDM4E B2RXH2 2/20 0.68
MAPT P10636 2/20 0.68
APAF1 O14727 1/20 0.68
POLB P06746 1/20 0.68
RECQL P46063 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
ITGB2 P05107 3/20 0.66
ICAM1 P05362 3/20 0.66
ITGAL P20701 3/20 0.66
SMN1; SMN2 Q16637 1/20 0.65
MEN1 O00255 1/20 0.63
LMNA P02545 1/20 0.63
MPO P05164 1/20 0.63
TSHR P16473 1/20 0.63
BLM P54132 1/20 0.63
PMP22 Q01453 1/20 0.63
KMT2A Q03164 1/20 0.63
HIF1A Q16665 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Abrine (L) SCHEMBL18777 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL29404678 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine (L) SCHEMBL29585648 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL161767 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL23668057 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL5056408 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL8871893 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL30320025 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL30413313 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine (L) SCHEMBL5056403 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8983 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075573-A Application of herba abri total saponin extract in preparation of medicine for treating MAFLD 2026-05-26 CN claimed
EP-4745237-A1 RNAI AGENT FOR INHIBITING EXPRESSION OF KETOHEXOKINASE AND USE THEREOF YUN HO BIO CO., LTD (CN) 2026-05-20 EP claimed
US-20260116920-A1 HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE PEPTIDREAM INC. (JP) 2026-04-30 US claimed
EP-4727654-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF Mariana Oncology Inc. (US) 2026-04-22 EP claimed
EP-4727655-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF Mariana Oncology Inc. (US) 2026-04-22 EP claimed
US-12600749-B2 Compstatin analogues and their medical uses ZP SPV 3 K/S (DK) 2026-04-14 US claimed
EP-3915587-B1 IMPROVED CELL-TARGETING BINDING MOLECULE SAPREME TECH BV (NL) 2026-03-25 EP claimed
US-20260069538-A1 CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-03-12 US claimed
EP-4667483-A1 HUMAN TRANSFERRIN RECEPTOR-BINDING PEPTIDE JCR Pharmaceuticals Co., Ltd. (JP) 2025-12-24 EP claimed
US-20250340595-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) BICYCLETX LTD (GB) 2025-11-06 US claimed
EP-0552417-A1 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-07-28 EP claimed
EP-0528312-A2 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-02-24 EP claimed
EP-0295526-B1 PROCESS AND DEVICE FOR SEPARATING AND TESTING WHOLE BLOOD MILES INC. (US) 1992-04-22 EP claimed
EP-0479910-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED Trp-Phe- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1992-04-15 EP claimed
US-5051351-A Sensitizers for silver halide emulsions EASTMAN KODAK COMPANY (US) 1991-09-24 US claimed
WO-1991000274-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED TRP-PHE- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1991-01-10 WO claimed
EP-0405537-A1 N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives WARNER-LAMBERT COMPANY (US) 1991-01-02 EP claimed
EP-0378318-A1 Process for synthesis of FK-506 and tricarbonyl intermediates MERCK & CO. INC. (US) 1990-07-18 EP claimed
CN-88102026-A CHEMO-RADIO-IMMUNO-CONJUGATES 1988-09-28 CN claimed
US-4622420-A Chelating agents and method THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1986-11-11 US claimed