Abrine (L)

Abrine (L)

SCHEMBL18777

CNC(Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.70
ACE P12821 3/20 0.69
KDM4E B2RXH2 2/20 0.68
MAPT P10636 2/20 0.68
APAF1 O14727 1/20 0.68
POLB P06746 1/20 0.68
RECQL P46063 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
ITGB2 P05107 3/20 0.66
ICAM1 P05362 3/20 0.66
ITGAL P20701 3/20 0.66
SMN1; SMN2 Q16637 1/20 0.65
MEN1 O00255 1/20 0.63
LMNA P02545 1/20 0.63
MPO P05164 1/20 0.63
TSHR P16473 1/20 0.63
BLM P54132 1/20 0.63
PMP22 Q01453 1/20 0.63
KMT2A Q03164 1/20 0.63
HIF1A Q16665 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Abrine SCHEMBL29404678 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine (L) SCHEMBL29585648 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL18778 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL161767 1.00 ALOX15 (0.70) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL23668057 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL5056408 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL8871893 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL30320025 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine SCHEMBL30413313 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1
Abrine (L) SCHEMBL5056403 0.99 ALOX15 (0.69) ALOX15ACEKDM4EMAPTAPAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1752 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116920-A1 HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE PEPTIDREAM INC. (JP) 2026-04-30 US claimed
EP-4667483-A1 HUMAN TRANSFERRIN RECEPTOR-BINDING PEPTIDE JCR Pharmaceuticals Co., Ltd. (JP) 2025-12-24 EP claimed
US-20250340595-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) BICYCLETX LTD (GB) 2025-11-06 US claimed
CN-113785191-B Digital microfluidic agglutination assay 多伦多大学管理委员会 2025-05-30 CN claimed
CN-119613495-A C3 complement inhibition polypeptide, preparation method and medical application thereof 远森制药(杭州)有限公司 2025-03-14 CN claimed
US-20250064950-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR P-SELECTIN BICYCLETX LIMITED (GB) 2025-02-27 US claimed
EP-4502269-A1 SUPERCRITICAL CARBON DIOXIDE FLUID DYEING METHOD FEATURING HIGH DYE UPTAKE OF DISPERSE DYE Qingdao Jifa Group Co., Ltd (CN) 2025-02-05 EP claimed
CN-119158034-A Bicyclic peptide ligands specific for conjugated protein-4 拜斯科技术开发有限公司 2024-12-20 CN claimed
US-20240391959-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) BICYCLETX LIMITED (GB) 2024-11-28 US claimed
US-12150998-B2 Bicyclic peptide ligands specific for P-selectin BICYCLETX LIMITED (GB) 2024-11-26 US claimed
EP-0775158-A1 ORGANIC COMPOUNDS SANDOZ LTD (CH) 1997-05-28 EP claimed
EP-0714909-A1 Composition for prophylaxis or treatment of pulmonary circulatory diseases Takeda Chemical Industries, Ltd. (JP) 1996-06-05 EP claimed
WO-1996003430-A1 ORGANIC COMPOUNDS SANDOZ LTD. (CH) 1996-02-08 WO claimed
EP-0552417-A1 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-07-28 EP claimed
EP-0528312-A2 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-02-24 EP claimed
EP-0479910-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED Trp-Phe- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1992-04-15 EP claimed
WO-1991000274-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED TRP-PHE- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1991-01-10 WO claimed
EP-0405537-A1 N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives WARNER-LAMBERT COMPANY (US) 1991-01-02 EP claimed
EP-0378318-A1 Process for synthesis of FK-506 and tricarbonyl intermediates MERCK & CO. INC. (US) 1990-07-18 EP claimed
US-4622420-A Chelating agents and method THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1986-11-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260116920-A1 HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE MET, TFRC, SLC7A1 ALOX15 4394/4885ACE 4448/4885KDM4E 1050/4885
US-20240391959-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) TFRC, FTH1, SLC40A1 ALOX15 3732/4885ACE 3093/4885KDM4E 4566/4885
US-20250340595-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) TFRC, FTH1, SLC40A1 ALOX15 3732/4885ACE 3093/4885KDM4E 4566/4885
US-12150998-B2 Bicyclic peptide ligands specific for P-selectin SELP, SELPLG, SELE ALOX15 840/4885ACE 110/4885KDM4E 4315/4885
US-20250064950-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR P-SELECTIN SELP, SELPLG, SELE ALOX15 840/4885ACE 110/4885KDM4E 4315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.