Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780323 | 0.84 | BTK (0.52) | F10BTK | |
| SCHEMBL18780265 | 0.82 | BTK (0.52) | F10ATRBTK | |
| SCHEMBL18800767 | 0.82 | RAB9A (0.48) | RAB9AMEN1KMT2AF10ATR | |
| SCHEMBL6115872 | 0.81 | BTK (0.49) | RAB9AMEN1KMT2AATRADORA2A | |
| SCHEMBL16168586 | 0.81 | BTK (0.48) | MEN1KMT2AF10BTKALDH1A1 | |
| SCHEMBL18780296 | 0.80 | MEN1 (0.49) | MEN1KMT2ABTKPARP14PARP10 | |
| SCHEMBL18800807 | 0.80 | ATR (0.48) | RAB9AF10ATRADORA2AADORA1 | |
| SCHEMBL18780329 | 0.79 | PLAU (0.53) | RAB9AMEN1KMT2AATRBTK | |
| SCHEMBL18780327 | 0.79 | BTK (0.54) | RAB9AMEN1KMT2AF10HPGD | |
| SCHEMBL18780383 | 0.79 | NPC1 (0.54) | F10ATRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |