Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 10/20 | 0.48 |
| ▸ | F2 | P00734 | 8/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 3/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.45 |
| ▸ | DCK | P27707 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16168586 | 0.88 | BTK (0.48) | BTKF2F10 | |
| SCHEMBL18780323 | 0.88 | BTK (0.52) | BTKF2F10MAP4K4 | |
| SCHEMBL18800404 | 0.86 | NPC1 (0.53) | NPC1PKMST14F2PRSS1 | |
| SCHEMBL18780329 | 0.86 | PLAU (0.53) | NPC1BTKF2PRSS1ATR | |
| SCHEMBL18780265 | 0.84 | BTK (0.52) | BTKF2F10ATR | |
| SCHEMBL18780337 | 0.83 | BTK (0.48) | NPC1BTKPKMST14F2 | |
| SCHEMBL6116157 | 0.81 | NPC1 (0.53) | NPC1BTKPKMATR | |
| SCHEMBL18780327 | 0.80 | BTK (0.54) | NPC1BTKF2F10 | |
| SCHEMBL18780267 | 0.79 | BTK (0.53) | NPC1BTKF2F10 | |
| SCHEMBL18780338 | 0.79 | RAB9A (0.50) | BTKF10ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |