Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067670 | 1.00 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL8193907 | 0.95 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL5658103 | 0.83 | KDM4E (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL8222045 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL3921349 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL3921342 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL998720 | 0.73 | DRD2 (0.38) | — | |
| SCHEMBL6437642 | 0.73 | — | — | |
| SCHEMBL7390574 | 0.72 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL1162066 | 0.72 | KDM4E (0.35) | SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293750-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-23 | — | — | US | disclosed |
| US-8183371-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | OPRD1, OPRK1, OPRL1 | CHRNB2 138/4885CHRNA4 141/4885CHRNA7 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.