Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 6/20 | 0.56 |
| ▸ | OGG1 | O15527 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1459893 | 0.85 | OGG1 (0.55) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18329647 | 0.83 | SMN1; SMN2 (0.61) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5487653 | 0.82 | NR1H4 (0.56) | ALDH1A1SMN1; SMN2RAB9ANPC1OGG1 | |
| SCHEMBL13753864 | 0.82 | HPGD (0.68) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6659819 | 0.80 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2648578 | 0.79 | OGG1 (0.57) | ALDH1A1SMN1; SMN2RAB9ANPC1OGG1 | |
| SCHEMBL21638086 | 0.79 | OGG1 (0.57) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30015840 | 0.79 | OGG1 (0.57) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1628213 | 0.79 | ALDH1A1 (0.57) | ALDH1A1OGG1TDP1KDM4ELMNA | |
| SCHEMBL4809042 | 0.79 | MAPT (0.66) | ALDH1A1SMN1; SMN2OGG1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10292981-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2019-05-21 | — | — | US | disclosed |
| US-10000458-B2 | Production method of 1, 2, 4-triazole compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-06-19 | — | — | US | disclosed |
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2017-10-26 | — | — | US | disclosed |
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2017-10-26 | — | — | US | disclosed |
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2017-10-26 | — | — | US | disclosed |
| US-20170283383-A1 | PRODUCTION METHOD OF 1, 2, 4-TRIAZOLE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-10-05 | — | — | US | disclosed |
| US-20170283383-A1 | PRODUCTION METHOD OF 1, 2, 4-TRIAZOLE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-10-05 | — | — | US | disclosed |
| US-9737534-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2017-08-22 | — | — | US | disclosed |
| US-9737534-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2017-08-22 | — | — | US | disclosed |
| US-9737534-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2017-08-22 | — | — | US | disclosed |
| EP-1435950-A1 | 2'-METHYL-5'-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| EP-1435949-A1 | 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032986-A1 | 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003032987-A1 | 2'-METHYL-5'-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| EP-0368237-B1 | Polymer bound flame retardants | ATOCHEM NORTH AMERICA (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5220015-A | Having hydrazide group to chemically bond to anhydride-containing polymers | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5140070-A | Halogenated aromatic compounds having acylamino functional groups bonded to imide containing polymer | ELF ATOCHEM NORTH AMERICA, INC (US) | 1992-08-18 | — | — | US | disclosed |
| US-5037894-A | Maleic anhydride polymer reacted with halogenated hydrazide compound or derivative | ATOCHEM NORTH AMERICA, INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0368237-A2 | Polymer bound flame retardants | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1990-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000458-B2 | Production method of 1, 2, 4-triazole compound | HRH4, HRH3, HRH2 | HPGD 1759/4885ALDH1A1 362/4885SMN1; SMN2 4851/4885 |
| US-10292981-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | RYR2, RYR1, ADRA2C | HPGD 1592/4885ALDH1A1 655/4885SMN1; SMN2 900/4885 |
| US-20170304299-A1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | RYR2, ADRA2C, RYR1 | HPGD 1620/4885ALDH1A1 607/4885SMN1; SMN2 856/4885 |
| US-20170283383-A1 | PRODUCTION METHOD OF 1, 2, 4-TRIAZOLE COMPOUND | HRH4, HRH3, HRH2 | HPGD 1759/4885ALDH1A1 362/4885SMN1; SMN2 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.