Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18784242 | 0.85 | CSNK2A1 (0.40) | TP53MAPTMAPK1LMNACSNK2A1 | |
| SCHEMBL18784223 | 0.80 | CSNK2A1 (0.39) | TP53MAPTMAPK1LMNACSNK2A1 | |
| SCHEMBL18784228 | 0.78 | CSNK2A1 (0.41) | CSNK2A1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1648897 | 0.78 | METAP2 (0.41) | BRD4ALDH1A1TP53MAPTLMNA | |
| Hydrochloric Acid SCHEMBL1649195 | 0.77 | METAP2 (0.41) | BRD4ALDH1A1TP53MAPTLMNA | |
| SCHEMBL18784246 | 0.74 | HTR7 (0.43) | ALDH1A1CSNK2A1SMN1; SMN2KDM4E | |
| SCHEMBL18784252 | 0.74 | KDM4E (0.41) | ALDH1A1LMNAHTTCSNK2A1GAA | |
| SCHEMBL18784214 | 0.72 | CSNK2A1 (0.36) | MAPTCSNK2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL1647710 | 0.69 | METAP2 (0.50) | BRD4ALDH1A1TP53MAPTLMNA | |
| SCHEMBL3573637 | 0.69 | CSNK2A1 (0.55) | ALDH1A1MAPTLMNACSNK2A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | claimed |