Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | NAT1 | P18440 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18784242 | 0.86 | CSNK2A1 (0.40) | KDM4EHTR6SPHK2SPHK1NAT1 | |
| SCHEMBL18784246 | 0.86 | HTR7 (0.43) | KDM4EHTR6SPHK1ALDH1A1HRH1 | |
| SCHEMBL18784223 | 0.85 | CSNK2A1 (0.39) | HTR6SPHK2SPHK1NAT1LMNA | |
| SCHEMBL18784214 | 0.82 | CSNK2A1 (0.36) | KDM4ESPHK2SPHK1NAT1GAA | |
| SCHEMBL1647731 | 0.77 | METAP2 (0.42) | KDM4EHTR6HDAC8HDAC6NAT1 | |
| SCHEMBL18784213 | 0.76 | SLC6A4 (0.36) | HTR6CSNK2A1 | |
| SCHEMBL18784228 | 0.76 | CSNK2A1 (0.41) | HTR6MCL1CSNK2A1 | |
| Hydrochloric Acid SCHEMBL1650055 | 0.76 | METAP2 (0.41) | KDM4EHTR6HDAC8HDAC6NAT1 | |
| SCHEMBL18784233 | 0.74 | BRD4 (0.41) | KDM4ELMNAALDH1A1GAATDP1 | |
| SCHEMBL18784244 | 0.74 | CSNK2A1 (0.40) | HTR6HDAC6NAT1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | claimed |