Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18784772 | 0.94 | CYP11B2 (0.40) | CYP11B2CYP11B1KCNH2CYP19A1RHEB | |
| SCHEMBL18784781 | 0.92 | CYP11B2 (0.40) | CYP11B2CYP11B1KCNH2CYP19A1CYP2A6 | |
| SCHEMBL18784784 | 0.92 | CYP11B2 (0.40) | CYP11B2CYP11B1KCNH2CYP19A1BRD4 | |
| SCHEMBL29613088 | 0.90 | CYP11B2 (0.41) | CYP11B2CYP11B1KCNH2CYP19A1CYP2A6 | |
| SCHEMBL18784762 | 0.90 | CYP11B2 (0.41) | CYP11B2CYP11B1KCNH2CYP19A1CYP2A6 | |
| SCHEMBL18784706 | 0.90 | CYP11B2 (0.42) | CYP11B2CYP11B1KCNH2CYP19A1CYP2A6 | |
| SCHEMBL22609651 | 0.87 | CYP11B2 (0.42) | CYP11B2CYP11B1KCNH2CYP19A1 | |
| SCHEMBL18784812 | 0.85 | KCNH2 (0.48) | CYP11B2CYP11B1KCNH2CYP19A1RHEB | |
| SCHEMBL18784718 | 0.85 | CYP11B2 (0.49) | CYP11B2CYP11B1KCNH2CYP19A1RHEB | |
| SCHEMBL18784836 | 0.84 | CYP11B2 (0.47) | CYP11B2CYP11B1KCNH2CYP19A1RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3162802-B1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDIPHYSICS CO LTD (JP) | 2020-08-19 | — | — | EP | disclosed |
| US-10358434-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20190169169-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICAMENT CONTAINING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-10189815-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-01-29 | — | — | US | disclosed |
| US-20170158668-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2017-06-08 | — | — | US | disclosed |
| EP-3162802-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169169-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICAMENT CONTAINING SAME | XDH, CYP11B2, GOT2 | CYP11B2 2/4885CYP11B1 30/4885KCNH2 978/4885 |
| US-20170158668-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | XDH, REN, BRD4 | CYP11B2 6/4885CYP11B1 19/4885KCNH2 415/4885 |
| US-10358434-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same | XDH, CYP11B2, GOT2 | CYP11B2 2/4885CYP11B1 30/4885KCNH2 978/4885 |
| US-10189815-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same | XDH, REN, BRD4 | CYP11B2 6/4885CYP11B1 19/4885KCNH2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.