Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 13/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 13/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 13/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019956 | 0.85 | POLB (0.67) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1871794 | 0.78 | POLB (0.63) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1043746 | 0.76 | L3MBTL1 (0.35) | ADRA1DADRA1AADRA1BHTR1ATSHR | |
| SCHEMBL6978317 | 0.76 | L3MBTL1 (0.35) | ADRA1DADRA1AADRA1BHTR1ATSHR | |
| SCHEMBL10864903 | 0.75 | POLB (0.97) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1019856 | 0.74 | ADRA1D (0.60) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1873324 | 0.74 | POLB (0.54) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1885058 | 0.73 | CA2 (0.40) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1875773 | 0.72 | POLB (0.62) | POLBESR2ADRA1DADRA1AADRA1B | |
| SCHEMBL6104984 | 0.72 | POLB (0.62) | POLBESR2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | DBH, SLC18A2, SLC6A3 | POLB 4159/4885ESR2 3143/4885ADRA1D 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.