Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18794873 | 0.79 | TACR1 (0.52) | TACR1RXRAP2RX1CES2RXRB | |
| SCHEMBL18794847 | 0.78 | TACR1 (0.48) | TACR1P2RX1CES2L3MBTL1 | |
| SCHEMBL1972923 | 0.76 | TACR1 (0.49) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6437793 | 0.74 | MEN1 (0.42) | — | |
| SCHEMBL25803948 | 0.74 | PSEN1 (0.37) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3289244 | 0.72 | AR (0.51) | RXRARXRBRXRG | |
| SCHEMBL18814523 | 0.72 | PSEN1 (0.62) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9135626 | 0.71 | CYP1A2 (0.43) | — | |
| SCHEMBL1969523 | 0.71 | CACNA1G (0.40) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30936758 | 0.71 | RIPK1 (0.40) | RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-06-11 | — | — | US | disclosed |
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-06-11 | — | — | US | disclosed |
| US-10604476-B2 | Fluorinated amide derivatives and their uses as therapeutic agents | TRILLIUM THERAPEUTICS INC. (CA) | 2020-03-31 | — | — | US | disclosed |
| US-20180334425-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-11-22 | — | — | US | disclosed |
| EP-3368509-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | Trillium Therapeutics Inc. (CA) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017070795-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017070795-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180334425-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | GRIN2A, ACHE, BDNF | TACR1 2047/4885PSEN1 83/4885PSEN2 75/4885 |
| US-10604476-B2 | Fluorinated amide derivatives and their uses as therapeutic agents | GRIN2A, ACHE, BDNF | TACR1 2047/4885PSEN1 83/4885PSEN2 75/4885 |
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | GRIN2A, ACHE, BDNF | TACR1 2047/4885PSEN1 83/4885PSEN2 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.