Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797090 | 0.85 | HTR1A (0.36) | MAOAADORA1ADORA3HTR1ACDK8 | |
| SCHEMBL18797093 | 0.84 | ADORA2A (0.38) | MAOAADORA1ADORA3HTR1AMAOB | |
| SCHEMBL18797105 | 0.81 | GAA (0.35) | MAOAHTR1ACDK8ACVR1PDE6D | |
| SCHEMBL17224789 | 0.78 | DHFR (0.43) | CDK8ACVR1MEN1MAPTKMT2A | |
| SCHEMBL30576349 | 0.78 | DHFR (0.43) | CDK8ACVR1MEN1MAPTKMT2A | |
| SCHEMBL11965000 | 0.74 | CDK8 (0.44) | CDK8ACVR1PDE6DPDE5APDE6A | |
| SCHEMBL15935620 | 0.70 | ESR2 (0.42) | CDK8ACVR1MEN1MAPTKMT2A | |
| SCHEMBL18797103 | 0.69 | KDM4E (0.36) | HTR1ACDK8ACVR1PDE6DPDE5A | |
| SCHEMBL17224744 | 0.69 | MCL1 (0.36) | ADORA1ADORA3CDK8ACVR1MAPT | |
| SCHEMBL30576372 | 0.69 | MCL1 (0.36) | ADORA1ADORA3CDK8ACVR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368523-B1 | NOVEL PYRIDAZINONE HERBICIDES | FMC CORP (US) | 2021-07-14 | — | — | EP | disclosed |
| CN-108495849-B | Pyridazinone herbicides | FMC公司 | 2020-11-10 | — | — | CN | disclosed |
| US-10750743-B2 | Pyridazinone herbicides | FMC CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180332851-A1 | NOVEL PYRIDAZINONE HERBICIDES | FMC CORPORATION | 2018-11-22 | — | — | US | disclosed |
| EP-3368523-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2018-09-05 | — | — | EP | disclosed |
| CN-108495849-A | Novel pyridazine herbicides | FMC公司 | 2018-09-04 | — | — | CN | disclosed |
| WO-2017074992-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10750743-B2 | Pyridazinone herbicides | PRDX4, PRDX6, PDXK | MAOA 899/4885ADORA1 884/4885ADORA3 382/4885 |
| US-20180332851-A1 | NOVEL PYRIDAZINONE HERBICIDES | PRDX4, PRDX6, PDXK | MAOA 1157/4885ADORA1 1072/4885ADORA3 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.