⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL754746 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL6829599 | 0.79 | ALDH1A1 (0.47) | — | |
| Tetrahydrofuran SCHEMBL6793997 | 0.77 | ALDH1A1 (0.44) | — | |
| Oxirane SCHEMBL17709710 | 0.76 | TTR (0.36) | — | |
| Cyclohexane SCHEMBL65948 | 0.75 | — | — | |
| Fluoride SCHEMBL27330547 | 0.75 | — | — | |
| Dioxane SCHEMBL1879738 | 0.73 | TTR (0.43) | — | |
| Isopropyl Alcohol SCHEMBL4414291 | 0.73 | ALDH1A1 (0.43) | — | |
| SCHEMBL4941244 | 0.73 | — | — | |
| Ethane SCHEMBL25176936 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612284-B | Substituted indoline derivatives as dengue virus replication inhibitors | 杨森制药公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-110461831-B | Substituted indoline derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2022-11-01 | — | — | CN | disclosed |
| US-11179368-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2021-11-23 | — | — | US | disclosed |
| US-11083707-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2021-08-10 | — | — | US | disclosed |
| EP-3601225-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2021-06-02 | — | — | EP | disclosed |
| EP-3601266-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2021-04-28 | — | — | EP | disclosed |
| US-20200121647-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2020-04-23 | — | — | US | disclosed |
| US-20200054606-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2020-02-20 | — | — | US | disclosed |
| EP-3601225-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| EP-3601266-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2012119653-A1 | PROCESS FOR MAKING CRYSTALLINE FORM A OF LINEZOLID | SYNTHON BV (NL) | 2012-09-13 | — | — | WO | disclosed |
| EP-2493867-A1 | PROCESS FOR MAKING CRYSTALLINE FORM A OF LINEZOLID | Synthon BV (NL) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051384-A1 | PROCESS FOR MAKING CRYSTALLINE FORM A OF LINEZOLID | SYNTHON BV (NL) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011050865-A1 | PROCESS FOR MAKING CRYSTALLINE FORM A OF LINEZOLID | SYNTHON B.V. (NL) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011050826-A1 | PROCESS FOR MAKING CRYSTALLINE FORM A OF LINEZOLID | SYNTHON B.V. (NL) | 2011-05-05 | — | — | WO | disclosed |
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-5356922-A | Treatment of disturbances in microcirculation | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-5232922-A | Cardiovascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-03 | — | — | US | disclosed |